Detailed information of TA system TA055278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 1321278..1322131
• Replicon: chromosome
• Accession: NZ_CP011964
• Organism: Bifidobacterium longum subsp. longum strain NCIMB8809

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V6XWY1
• Locus tag: B8809_RS05600
• Protein ID: WP_007054468.1
• Coordinates: 1321278..1321769 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B8809_RS05605
• Protein ID: WP_058062650.1
• Coordinates: 1321769..1322131 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B8809_RS05580	1316361..1317593	+	1233	WP_007056207.1	sensor histidine kinase	-
B8809_RS05585	1317628..1318353	+	726	WP_007056206.1	response regulator transcription factor	-
B8809_RS05590	1318393..1319034	+	642	WP_007052627.1	GNAT family N-acetyltransferase	-
B8809_RS05595	1319124..1321228	+	2105	Protein_1089	DUF262 domain-containing protein	-
B8809_RS05600	1321278..1321769	-	492	WP_007054468.1	PIN domain-containing protein	Toxin
B8809_RS05605	1321769..1322131	-	363	WP_058062650.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
B8809_RS05610	1322276..1324975	-	2700	WP_058062651.1	aconitate hydratase AcnA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1263923..1342445	78522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-61)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18328.91 Da
• Isoelectric Point: 4.5590

>T55278 WP_007054468.1 NZ_CP011964:c1321769-1321278 [Bifidobacterium longum subsp. longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNITLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T55278 NZ_CP011964:c1321769-1321278 [Bifidobacterium longum subsp. longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACATTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAACTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13915.99 Da
• Isoelectric Point: 5.3491

>AT55278 WP_058062650.1 NZ_CP011964:c1322131-1321769 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREAEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Nucleotide

• Length: 363 bp

>AT55278 NZ_CP011964:c1322131-1321769 [Bifidobacterium longum subsp. longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAGGCCCGCGAGGCGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Structures

Toxin

• AlphaFold DB: V6XWY1