Detailed information of TA system TA055247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4419359..4420173
• Replicon: chromosome
• Accession: NZ_CP011938
• Organism: Escherichia coli strain C43(DE3)

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: TZ57_RS21830
• Protein ID: WP_001054376.1
• Coordinates: 4419916..4420173 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: TZ57_RS21825
• Protein ID: WP_001309181.1
• Coordinates: 4419359..4419904 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TZ57_RS21805	4415050..4416363	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
TZ57_RS21810	4416375..4416653	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
TZ57_RS21815	4416650..4417771	-	1122	WP_000010829.1	M42 family metallopeptidase	-
TZ57_RS25240	4418016..4418132	-	117	Protein_4141	VOC family protein	-
TZ57_RS24645	4418170..4418388	-	219	Protein_4142	hypothetical protein	-
TZ57_RS21820	4418557..4419303	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
TZ57_RS21825	4419359..4419904	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
TZ57_RS21830	4419916..4420173	-	258	WP_001054376.1	hypothetical protein	Toxin
TZ57_RS25060	4420550..4420795	-	246	Protein_4146	GNAT family N-acetyltransferase	-
TZ57_RS21845	4420911..4422151	+	1241	Protein_4147	helicase YjhR	-
TZ57_RS21850	4422734..4423714	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
TZ57_RS21855	4423779..4424885	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T55247 WP_001054376.1 NZ_CP011938:c4420173-4419916 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T55247 NZ_CP011938:c4420173-4419916 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT55247 WP_001309181.1 NZ_CP011938:c4419904-4419359 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT55247 NZ_CP011938:c4419904-4419359 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8