Detailed information of TA system TA055211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3070618..3071320
• Replicon: chromosome
• Accession: NZ_CP011930
• Organism: Herbaspirillum seropedicae strain Z67

Toxin (Protein)

• Gene name: tad
• Uniprot ID: D8IXT6
• Locus tag: ACP92_RS13465
• Protein ID: WP_013234666.1
• Coordinates: 3070618..3071004 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: ACP92_RS13470
• Protein ID: WP_041311942.1
• Coordinates: 3070985..3071320 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACP92_RS13435	3065646..3066668	-	1023	WP_041310849.1	TRAP transporter substrate-binding protein DctP	-
ACP92_RS13440	3066815..3067483	+	669	WP_013234661.1	GntR family transcriptional regulator	-
ACP92_RS13445	3067495..3068394	-	900	WP_013234662.1	pseudouridine synthase	-
ACP92_RS13450	3068391..3069731	-	1341	WP_013234663.1	type II toxin-antitoxin system HipA family toxin	-
ACP92_RS13455	3069728..3070030	-	303	WP_013234664.1	helix-turn-helix domain-containing protein	-
ACP92_RS13460	3070216..3070404	-	189	WP_013234665.1	YjfB family protein	-
ACP92_RS13465	3070618..3071004	+	387	WP_013234666.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACP92_RS13470	3070985..3071320	+	336	WP_041311942.1	helix-turn-helix domain-containing protein	Antitoxin
ACP92_RS13475	3071400..3071588	-	189	WP_041311945.1	hypothetical protein	-
ACP92_RS13480	3071771..3072607	-	837	WP_013234669.1	anti-sigma factor	-
ACP92_RS13485	3072604..3073158	-	555	WP_048348571.1	RNA polymerase sigma factor	-
ACP92_RS13490	3073182..3073553	-	372	WP_013234671.1	hypothetical protein	-
ACP92_RS13495	3073666..3074100	-	435	WP_013234672.1	group 1 truncated hemoglobin	-
ACP92_RS13500	3074112..3075095	-	984	WP_048348713.1	DUF3034 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-93)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14387.57 Da
• Isoelectric Point: 9.9479

>T55211 WP_013234666.1 NZ_CP011930:3070618-3071004 [Herbaspirillum seropedicae]
MHGKEKPLEWIGSSYKDLMALPSAIRQRFGYALSLAQLGDRDDAAKVLRGFGDAGVLEIIEDEASGTYRAVYVIRFEEAV
FVLHCFQKKSKHGIATPKTDIDIIRTRLKVAAARAEELRHARHAKKNH

Nucleotide

• Length: 387 bp

>T55211 NZ_CP011930:3070618-3071004 [Herbaspirillum seropedicae]
ATGCACGGTAAAGAAAAACCACTTGAATGGATAGGTAGCAGCTACAAGGACCTCATGGCACTGCCATCAGCCATTCGTCA
GCGCTTTGGTTATGCCCTATCGTTGGCACAACTGGGAGATCGCGACGACGCAGCCAAAGTTCTAAGAGGATTTGGAGACG
CAGGCGTGCTGGAAATCATTGAGGATGAGGCCAGCGGCACCTATCGGGCGGTGTACGTGATCAGGTTCGAAGAGGCGGTC
TTCGTCCTCCATTGCTTCCAGAAGAAAAGCAAGCACGGTATTGCCACCCCGAAAACCGACATCGATATCATACGGACACG
GCTGAAAGTCGCCGCCGCACGCGCAGAGGAGCTAAGACATGCACGACATGCAAAGAAGAACCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12276.35 Da
• Isoelectric Point: 10.3997

>AT55211 WP_041311942.1 NZ_CP011930:3070985-3071320 [Herbaspirillum seropedicae]
MQRRTIDDTPILRSSDNVFADLGLPDADKLKIKTALVVEIRKALRTLGLTQQAAAKRMGISQPKVSGMMRGDFSNLSERK
LMDCLNRLGYDIEIKLHPTSAVQGHLTLTVA

Nucleotide

• Length: 336 bp

>AT55211 NZ_CP011930:3070985-3071320 [Herbaspirillum seropedicae]
ATGCAAAGAAGAACCATTGACGACACCCCTATCTTGCGCAGTTCAGACAATGTCTTCGCCGACCTCGGTCTGCCCGATGC
GGACAAGCTCAAAATCAAGACTGCCCTGGTGGTTGAAATCCGCAAAGCCTTACGTACACTCGGACTCACCCAACAGGCCG
CAGCCAAGCGCATGGGGATCTCCCAACCCAAGGTGTCAGGCATGATGCGTGGCGATTTCAGCAATCTGTCGGAACGCAAG
CTGATGGATTGCCTGAACCGACTGGGCTATGACATCGAGATCAAATTGCATCCGACCAGCGCTGTTCAGGGTCACCTGAC
ATTGACGGTGGCGTGA

Structures

Toxin

• AlphaFold DB: D8IXT6