Detailed information of TA system TA055209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2503727..2504394
• Replicon: chromosome
• Accession: NZ_CP011930
• Organism: Herbaspirillum seropedicae strain Z67

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D8IU60
• Locus tag: ACP92_RS11065
• Protein ID: WP_013234201.1
• Coordinates: 2503978..2504394 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ACP92_RS11060
• Protein ID: WP_013234200.1
• Coordinates: 2503727..2503981 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACP92_RS11050	2500372..2501976	-	1605	WP_013234198.1	L-aspartate oxidase	-
ACP92_RS11055	2502143..2503354	-	1212	WP_013234199.1	formate-dependent phosphoribosylglycinamide formyltransferase	-
ACP92_RS11060	2503727..2503981	+	255	WP_013234200.1	plasmid stabilization protein	Antitoxin
ACP92_RS11065	2503978..2504394	+	417	WP_013234201.1	type II toxin-antitoxin system VapC family toxin	Toxin
ACP92_RS11070	2504419..2504721	-	303	WP_013234202.1	hypothetical protein	-
ACP92_RS11075	2504723..2506078	-	1356	WP_013234203.1	DUF1446 domain-containing protein	-
ACP92_RS11080	2506121..2507422	-	1302	WP_048348538.1	citrate:proton symporter	-
ACP92_RS11085	2507607..2508494	+	888	Protein_2210	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14945.23 Da
• Isoelectric Point: 5.1150

>T55209 WP_013234201.1 NZ_CP011930:2503978-2504394 [Herbaspirillum seropedicae]
MIVLDTNVVSEAMKPAPDAAVQAWFNDQAPDTLYLTSITVAEIGFGIACLSAGRRQDLLARRFEGLLRMFKDRILPFDMD
AARSHAELAAMARRAGRGFPTPDGYIAAIAASCGFLVASRDVTPYLAAELTVINPWQA

Nucleotide

• Length: 417 bp

>T55209 NZ_CP011930:2503978-2504394 [Herbaspirillum seropedicae]
ATGATCGTCCTGGATACCAACGTGGTGTCCGAGGCCATGAAGCCTGCCCCGGACGCCGCCGTACAGGCCTGGTTCAATGA
CCAGGCACCCGACACGCTCTACCTGACCAGCATTACGGTGGCCGAGATCGGCTTCGGCATAGCCTGCCTGTCTGCTGGCC
GTCGCCAGGATTTGCTGGCGCGTCGCTTCGAGGGCTTGCTGCGCATGTTCAAGGACCGCATCCTGCCCTTCGATATGGAC
GCCGCACGCTCGCATGCCGAGCTGGCCGCCATGGCCAGGCGTGCAGGCCGGGGATTTCCCACGCCGGATGGCTACATAGC
CGCCATTGCCGCTTCCTGCGGATTCCTCGTGGCGTCGCGCGATGTCACCCCTTATCTGGCCGCAGAGCTGACGGTCATCA
ATCCCTGGCAAGCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9288.55 Da
• Isoelectric Point: 6.4677

>AT55209 WP_013234200.1 NZ_CP011930:2503727-2503981 [Herbaspirillum seropedicae]
MATLTVRNLPDEVHRALRVRAAQHGRSTEAEIREILTLAVRPAGQLRLGDALAAMSRELGLSNEDVEALQQTRERAPAQP
MSFE

Nucleotide

• Length: 255 bp

>AT55209 NZ_CP011930:2503727-2503981 [Herbaspirillum seropedicae]
ATGGCCACCCTCACAGTCCGGAACCTCCCCGACGAGGTCCATCGCGCCCTGCGCGTGCGCGCGGCCCAGCATGGCCGCAG
CACCGAGGCGGAAATCCGCGAGATTCTCACCCTGGCAGTCAGGCCTGCCGGACAACTGCGCCTGGGAGACGCCCTGGCGG
CAATGAGCCGAGAGCTGGGTCTGAGCAATGAAGATGTCGAAGCCCTGCAGCAGACCCGCGAACGTGCGCCAGCCCAACCG
ATGAGTTTCGAATGA

Structures

Toxin

• AlphaFold DB: D8IU60