Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 445805..447435 Replicon chromosome
Accession NZ_CP011930
Organism Herbaspirillum seropedicae strain Z67

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ACP92_RS02045 Protein ID WP_048348487.1
Coordinates 446113..447435 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ACP92_RS02040 Protein ID WP_013232456.1
Coordinates 445805..446074 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACP92_RS02015 440884..442281 - 1398 WP_041310025.1 M23 family metallopeptidase -
ACP92_RS02020 442539..443789 + 1251 WP_041310028.1 tyrosine--tRNA ligase -
ACP92_RS02025 443802..444275 + 474 WP_013232453.1 D-tyrosyl-tRNA(Tyr) deacylase -
ACP92_RS02030 444362..445009 + 648 WP_013232454.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
ACP92_RS02035 445019..445663 + 645 WP_013232455.1 histidine phosphatase family protein -
ACP92_RS02040 445805..446074 + 270 WP_013232456.1 helix-turn-helix domain-containing protein Antitoxin
ACP92_RS02045 446113..447435 + 1323 WP_048348487.1 type II toxin-antitoxin system HipA family toxin Toxin
ACP92_RS02050 447599..448621 + 1023 WP_013232458.1 tRNA dihydrouridine synthase DusB -
ACP92_RS02055 448800..449033 + 234 WP_006463627.1 Fis family transcriptional regulator -
ACP92_RS02060 449131..450702 + 1572 WP_013232459.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
ACP92_RS02065 450814..451857 - 1044 WP_013232460.1 MerR family transcriptional regulator -
ACP92_RS24135 451952..452131 + 180 WP_081441873.1 DUF2256 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(143-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48444.86 Da        Isoelectric Point: 6.8740

>T55208 WP_048348487.1 NZ_CP011930:446113-447435 [Herbaspirillum seropedicae]
MNGSFVGTWALTAQGDSLQYDARWVVSASGRPLSLSLPFRPGNPPHRGDLVRHYFENLLPDSKAIRERLARRYQAADTDA
FALLGEAGRDCVGALQILPLGATPELSWTIDARPLREREVAELLRQTMEPTPLALTQGEELRLSIAGAQEKTALLRYLDQ
WCLPHGATPTTHILKLPMGLVGGLQLDLRHSVENEWLCSRILAAYGMPVAACDIFCFEDQKVLAVERFDRRWSRDPASGQ
TMLLRLPQEDMCQATGISPWLKYEADGGPGMKEIMALLGGAIDPVAARRHFFKAQLLFWMLWATDGHAKNFSLFLKAGGR
YEPTPLYDVLSVFPLIGEGPGKLSPHRAAMAMAVRAKNAHRKMKDILPRHWMALGSHFGIVAENGDGPLAILEELAEQTE
QVIAKVQADLPPGFPSELAASILDGLRRSASSLLSFVQTA

Download         Length: 1323 bp

>T55208 NZ_CP011930:446113-447435 [Herbaspirillum seropedicae]
ATGAATGGCAGTTTCGTGGGGACCTGGGCGCTGACAGCGCAAGGAGACAGCCTGCAATACGACGCCCGCTGGGTCGTCTC
CGCCAGCGGCCGGCCATTGTCGCTTTCCCTTCCTTTCCGGCCGGGCAATCCTCCCCATCGCGGCGACCTTGTCAGGCATT
ATTTCGAAAACCTGCTGCCTGACAGCAAAGCCATTCGCGAGCGACTGGCACGCCGTTACCAGGCAGCCGATACCGATGCC
TTCGCCCTGCTGGGCGAAGCCGGCCGCGATTGCGTGGGGGCCTTGCAGATATTGCCCCTTGGCGCCACGCCTGAGCTGTC
CTGGACCATTGACGCCCGCCCCTTGCGTGAACGGGAGGTGGCCGAACTGCTGCGCCAGACCATGGAACCGACGCCCCTGG
CCCTGACCCAGGGCGAAGAGTTGCGGCTTTCCATTGCCGGCGCCCAGGAAAAGACCGCCTTGCTGCGTTACCTTGACCAA
TGGTGTTTGCCGCATGGCGCCACGCCTACCACCCATATCCTGAAACTGCCCATGGGCCTGGTTGGCGGGCTCCAGCTCGA
TTTGCGCCATTCGGTCGAGAATGAGTGGCTGTGCTCACGCATCCTCGCCGCGTATGGGATGCCGGTCGCCGCCTGTGACA
TCTTCTGTTTCGAAGACCAGAAGGTGCTGGCGGTGGAACGCTTCGACCGCCGCTGGAGCCGGGACCCCGCGAGCGGCCAG
ACCATGCTGCTGCGCTTGCCGCAAGAAGACATGTGCCAGGCTACCGGCATCTCTCCCTGGTTGAAATATGAAGCCGATGG
CGGCCCCGGCATGAAGGAGATCATGGCCTTGCTGGGCGGCGCTATCGATCCGGTGGCCGCGCGTCGGCATTTCTTCAAGG
CGCAGCTGCTGTTCTGGATGCTGTGGGCCACCGATGGTCATGCCAAGAATTTCTCGCTGTTCCTCAAGGCGGGGGGGCGC
TACGAACCCACGCCCCTGTATGACGTGCTGTCGGTGTTTCCGCTCATTGGCGAAGGGCCGGGCAAACTCTCACCCCATCG
CGCGGCCATGGCCATGGCAGTACGCGCCAAGAATGCCCATCGCAAGATGAAGGACATCCTGCCCCGACACTGGATGGCGC
TGGGTAGTCATTTCGGTATCGTCGCCGAGAATGGCGACGGCCCCCTTGCCATCCTGGAGGAACTGGCCGAGCAGACGGAG
CAGGTCATTGCCAAGGTGCAAGCCGATCTGCCCCCAGGCTTCCCGTCAGAGCTGGCAGCCTCCATCCTGGATGGCCTGCG
TCGTTCGGCAAGCAGCCTCCTGTCATTCGTTCAAACTGCGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9886.26 Da        Isoelectric Point: 6.3161

>AT55208 WP_013232456.1 NZ_CP011930:445805-446074 [Herbaspirillum seropedicae]
MSEFPVRTGRQLPELLQAYRKQSGLTQSEVARRLGVTQQNLSSLERNADKVSAERLIELLNILGVELVLRKIEAAPSDAL
ASPSDTPQW

Download         Length: 270 bp

>AT55208 NZ_CP011930:445805-446074 [Herbaspirillum seropedicae]
ATGAGCGAATTTCCCGTCCGCACCGGCCGCCAGCTACCTGAGCTGTTGCAGGCCTATCGCAAGCAGTCTGGCCTGACCCA
AAGCGAGGTCGCGCGTCGCCTGGGCGTGACCCAGCAGAACCTGTCCTCGTTGGAGCGCAATGCCGACAAGGTGAGCGCTG
AGCGCCTCATCGAGCTGCTCAATATCCTTGGCGTCGAACTGGTGTTGCGCAAGATCGAAGCGGCCCCCTCCGACGCTCTT
GCTTCCCCCTCGGATACGCCCCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References