Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2326633..2328425 Replicon chromosome
Accession NZ_CP011918
Organism Burkholderia cenocepacia strain ST32 isolate 1232

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag TQ36_RS27860 Protein ID WP_058903253.1
Coordinates 2327529..2328425 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A364H4C6
Locus tag TQ36_RS27855 Protein ID WP_006496928.1
Coordinates 2326633..2327490 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TQ36_RS27835 2321796..2323286 - 1491 WP_006487205.1 aldehyde dehydrogenase -
TQ36_RS27840 2323359..2324186 - 828 WP_034202181.1 aspartate dehydrogenase -
TQ36_RS27845 2324179..2325846 - 1668 WP_006496930.1 thiamine pyrophosphate-binding protein -
TQ36_RS27850 2325839..2326636 - 798 WP_034202180.1 SDR family oxidoreductase -
TQ36_RS27855 2326633..2327490 - 858 WP_006496928.1 IclR family transcriptional regulator Antitoxin
TQ36_RS27860 2327529..2328425 - 897 WP_058903253.1 alpha/beta fold hydrolase Toxin
TQ36_RS27865 2328444..2328971 - 528 WP_006489904.1 cupin domain-containing protein -
TQ36_RS27870 2329006..2329776 - 771 WP_006489881.1 SDR family oxidoreductase -
TQ36_RS27875 2329769..2330839 - 1071 WP_006489909.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
TQ36_RS27880 2330894..2331205 - 312 WP_058903254.1 hypothetical protein -
TQ36_RS27885 2331207..2331524 - 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
TQ36_RS27890 2331969..2333048 + 1080 WP_006489902.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30571.77 Da        Isoelectric Point: 7.7327

>T55200 WP_058903253.1 NZ_CP011918:c2328425-2327529 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA

Download         Length: 897 bp

>T55200 NZ_CP011918:c2328425-2327529 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTCCGTCAGCTCGACACGCTGGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGGTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCAGCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTCCTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCGCCC
GCGTGACGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAGACCCGC
GAAGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTCCGGGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCAGGGCACGCCGGCTATGTGGAAGCGCCGGCCGCGTATTCCGCGCTGATCGACTCGTTCTGCCGGCAGTGCGATACGC
AGTGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31371.86 Da        Isoelectric Point: 6.5061

>AT55200 WP_006496928.1 NZ_CP011918:c2327490-2326633 [Burkholderia cenocepacia]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT55200 NZ_CP011918:c2327490-2326633 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGCAACAAAACGAATCCGAAAACGCGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
GTTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCTGAACTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
AAGCCTGCGCGATGCGACAGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGTTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCATGCAACGACACACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGTGCTGAACCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCTTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTGAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364H4C6

References