Detailed information of TA system TA055199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2145359..2145998
• Replicon: chromosome
• Accession: NZ_CP011918
• Organism: Burkholderia cenocepacia strain ST32 isolate 1232

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TQ36_RS27065
• Protein ID: WP_171984202.1
• Coordinates: 2145359..2145775 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: TQ36_RS27070
• Protein ID: WP_006481537.1
• Coordinates: 2145762..2145998 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TQ36_RS27040	2140466..2141566	-	1101	WP_058903172.1	nitronate monooxygenase	-
TQ36_RS27045	2141563..2142483	-	921	WP_006481536.1	enoyl-CoA hydratase	-
TQ36_RS27050	2142492..2143289	-	798	WP_006481539.1	hypothetical protein	-
TQ36_RS27055	2143300..2144193	-	894	WP_058903173.1	CoA transferase subunit A	-
TQ36_RS27060	2144203..2145099	-	897	WP_058903174.1	VOC family protein	-
TQ36_RS27065	2145359..2145775	-	417	WP_171984202.1	PIN domain-containing protein	Toxin
TQ36_RS27070	2145762..2145998	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
TQ36_RS27075	2146491..2147717	+	1227	WP_058903176.1	acyltransferase	-
TQ36_RS27080	2147728..2148405	-	678	WP_077175688.1	hypothetical protein	-
TQ36_RS27085	2149054..2149827	-	774	WP_058903177.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15390.58 Da
• Isoelectric Point: 6.8818

>T55199 WP_171984202.1 NZ_CP011918:c2145775-2145359 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALTNDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T55199 NZ_CP011918:c2145775-2145359 [Burkholderia cenocepacia]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGTTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCCTGGCTGACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGTTGACCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT55199 WP_006481537.1 NZ_CP011918:c2145998-2145762 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT55199 NZ_CP011918:c2145998-2145762 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCGGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGTGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554