Detailed information of TA system TA055198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1575113..1575759
• Replicon: chromosome
• Accession: NZ_CP011918
• Organism: Burkholderia cenocepacia strain ST32 isolate 1232

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TQ36_RS24570
• Protein ID: WP_058902965.1
• Coordinates: 1575352..1575759 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B4EGU8
• Locus tag: TQ36_RS24565
• Protein ID: WP_006491146.1
• Coordinates: 1575113..1575355 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TQ36_RS24550	1571109..1572515	+	1407	WP_006491136.1	aspartate ammonia-lyase	-
TQ36_RS24555	1572594..1574099	+	1506	WP_006491141.1	amino acid permease	-
TQ36_RS24560	1574171..1574854	-	684	WP_058902964.1	phospholipase	-
TQ36_RS24565	1575113..1575355	+	243	WP_006491146.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TQ36_RS24570	1575352..1575759	+	408	WP_058902965.1	type II toxin-antitoxin system VapC family toxin	Toxin
TQ36_RS37695	1575875..1576102	-	228	WP_077021721.1	hypothetical protein	-
TQ36_RS24575	1576160..1578535	+	2376	WP_058902966.1	MCP four helix bundle domain-containing protein	-
TQ36_RS24580	1578558..1579286	+	729	WP_058903588.1	chemotaxis protein	-
TQ36_RS24585	1579283..1579864	+	582	WP_058902967.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14893.96 Da
• Isoelectric Point: 5.8982

>T55198 WP_058902965.1 NZ_CP011918:1575352-1575759 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPNAD

Nucleotide

• Length: 408 bp

>T55198 NZ_CP011918:1575352-1575759 [Burkholderia cenocepacia]
ATGAAATTCCTGCTGGATACCAACGCGGTGATCGCCATTCTCAAAGGCGAGCCGGCGATACTGGCCCGTTTGCATGCCTG
GCACCCGGCCGATTTCGGGATTCCCGCGATCGTCGCGCACGAGCTTTACTACGGCGCGTACAAGAGCCAGCGAGCGGCTG
CGAACGTCGCGCGTGTCGACGCGTTGCAGTTCGAGGTCGTATCGTTCGACACCGAGGATGCACAGCATGCGGGTGAAATT
CGCGCGCACCTGATCGCGGCCGGCACGCCGATTGGTCCATACGACGCGTTGATCGCAGGGCAGGCGCGCGCACGACAACT
GGTGCTGGTCACGCACAACGTCCGCGAATTCGAGCGCGTTCCGCGGCTGCAATTCGAAGACTGGCTCGCCGAACCGAACG
CAGACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.02 Da
• Isoelectric Point: 5.0197

>AT55198 WP_006491146.1 NZ_CP011918:1575113-1575355 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Nucleotide

• Length: 243 bp

>AT55198 NZ_CP011918:1575113-1575355 [Burkholderia cenocepacia]
ATGGATACTGCAAAGCTCTTCAAGCATGGCGGCTCGCAGGCTGTCCGGCTACCGAAGGATTTCCGCTTCGATACGGCCGA
GGTTCGCATCCGCCGCCACGGGGCGGCCGTCATTCTCGAGCCGATGCCGCAAGACTGGGCTTGGCTGGCACCGCTGATCG
GTCCGGTGGACGCCGATTTCGAGGCTGCAGCGACCACACAGCCGTCCGCTCAGGAGCGCTCGGGCCTGGACGTGTTCGAA
TGA

Structures

Antitoxin

• AlphaFold DB: B4EGU8