Detailed information of TA system TA055196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 3583276..3583808
• Replicon: chromosome
• Accession: NZ_CP011917
• Organism: Burkholderia cenocepacia strain ST32 isolate 1232

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: TQ36_RS16335
• Protein ID: WP_058902188.1
• Coordinates: 3583276..3583599 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: B4EDC7
• Locus tag: TQ36_RS16340
• Protein ID: WP_012492929.1
• Coordinates: 3583596..3583808 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TQ36_RS16315	3578286..3579119	-	834	WP_034200961.1	class II glutamine amidotransferase	-
TQ36_RS16320	3579320..3579649	-	330	WP_006484989.1	carboxymuconolactone decarboxylase family protein	-
TQ36_RS16325	3579779..3580726	+	948	WP_058902187.1	AraC family transcriptional regulator	-
TQ36_RS16330	3580830..3581273	+	444	WP_011544671.1	YiaA/YiaB family protein	-
TQ36_RS37185	3581396..3582430	-	1035	WP_077021906.1	relaxase/mobilization nuclease domain-containing protein	-
TQ36_RS37190	3582432..3582956	-	525	WP_012492930.1	hypothetical protein	-
TQ36_RS16335	3583276..3583599	-	324	WP_058902188.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
TQ36_RS16340	3583596..3583808	-	213	WP_012492929.1	antitoxin MazE family protein	Antitoxin
TQ36_RS16345	3583953..3584237	-	285	Protein_3274	hypothetical protein	-
TQ36_RS16350	3584386..3585564	+	1179	WP_105773736.1	IS256 family transposase	-
TQ36_RS16355	3585601..3585783	-	183	Protein_3276	hypothetical protein	-
TQ36_RS16360	3585851..3586246	-	396	WP_171984189.1	hypothetical protein	-
TQ36_RS16365	3586385..3586705	+	321	WP_012492928.1	helix-turn-helix domain-containing protein	-
TQ36_RS16375	3587134..3587883	-	750	WP_006484965.1	tol-pal system protein YbgF	-
TQ36_RS16380	3587903..3588415	-	513	WP_006484980.1	peptidoglycan-associated lipoprotein Pal	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (7-67)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11666.79 Da
• Isoelectric Point: 8.9366

>T55196 WP_058902188.1 NZ_CP011917:c3583599-3583276 [Burkholderia cenocepacia]
MNRGSIVTVALQGDFGKARPALVVQSDLFAEHPSVTLLLMSSAMVDAPLIRITVLPSEQNGLRMPSQIAVDKMFTVRREK
IGRPIGHLEDELMVAVNRSLLVFLGLA

Nucleotide

• Length: 324 bp

>T55196 NZ_CP011917:c3583599-3583276 [Burkholderia cenocepacia]
ATGAATCGCGGGAGCATTGTCACAGTCGCGCTCCAAGGTGACTTCGGCAAGGCTCGGCCGGCGCTCGTGGTGCAGTCGGA
CCTGTTTGCCGAACATCCCAGCGTAACGTTGCTGCTAATGTCGAGCGCAATGGTCGATGCGCCCTTGATACGCATTACTG
TTCTCCCATCCGAGCAGAACGGCTTGCGCATGCCGTCCCAGATTGCCGTAGACAAAATGTTCACCGTGCGCCGCGAGAAA
ATCGGTCGCCCCATCGGCCACCTCGAAGATGAACTGATGGTTGCCGTCAATCGTTCGCTACTCGTTTTTCTAGGACTAGC
GTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8025.99 Da
• Isoelectric Point: 5.5492

>AT55196 WP_012492929.1 NZ_CP011917:c3583808-3583596 [Burkholderia cenocepacia]
MAATTSERVRIHRENLRAAGLRPIQIWVPDVRQPGFADECARQSRMVHQSIDENDLLDFIEQVTDLGHSQ

Nucleotide

• Length: 213 bp

>AT55196 NZ_CP011917:c3583808-3583596 [Burkholderia cenocepacia]
ATGGCAGCTACCACTTCCGAGCGTGTTCGAATTCACCGCGAGAATCTTCGTGCGGCCGGGCTACGTCCAATTCAGATATG
GGTGCCGGACGTCCGCCAGCCGGGTTTCGCCGATGAATGCGCTCGGCAATCGCGCATGGTCCACCAGAGCATCGACGAGA
ACGATCTGCTCGATTTCATTGAACAGGTTACGGACCTCGGACACTCACAATGA

Structures

Antitoxin

• AlphaFold DB: B4EDC7