Detailed information of TA system TA055194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 2906622..2907259
• Replicon: chromosome
• Accession: NZ_CP011917
• Organism: Burkholderia cenocepacia strain ST32 isolate 1232

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TQ36_RS13250
• Protein ID: WP_058902008.1
• Coordinates: 2906622..2907023 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A364GPY9
• Locus tag: TQ36_RS13255
• Protein ID: WP_034201144.1
• Coordinates: 2907023..2907259 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TQ36_RS13240	2903994..2905136	+	1143	WP_006485680.1	alginate lyase family protein	-
TQ36_RS13245	2905167..2906555	+	1389	WP_058902007.1	L-serine ammonia-lyase	-
TQ36_RS13250	2906622..2907023	-	402	WP_058902008.1	type II toxin-antitoxin system VapC family toxin	Toxin
TQ36_RS13255	2907023..2907259	-	237	WP_034201144.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TQ36_RS13260	2907377..2907606	-	230	Protein_2643	type II toxin-antitoxin system RelE/ParE family toxin	-
TQ36_RS13265	2907975..2909678	+	1704	WP_058902009.1	thiamine pyrophosphate-binding protein	-
TQ36_RS13270	2909675..2910772	+	1098	WP_058902010.1	hypothetical protein	-
TQ36_RS13275	2910882..2911898	-	1017	WP_006493582.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15043.22 Da
• Isoelectric Point: 5.6634

>T55194 WP_058902008.1 NZ_CP011917:c2907023-2906622 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGLTACANPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T55194 NZ_CP011917:c2907023-2906622 [Burkholderia cenocepacia]
ATGCCGCGCTTCATGCTCGACACCAACATGTGTATCTATCTGATGAAAAATCAGCCTGAGCAGGTCGCGAGACGGTTTGC
GCAGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCCTGACCGCTTGTGCGAATC
CCGCGCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCGGCGGCCGCGCAAGCG
TATGGCCCGGTTCGCGAGGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATTGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTTGTCACCAACAACGAGCGCGATTTCGTCAGCTATCCGGGATTGCGACTGGAGAACTGGCTGAACGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8982.15 Da
• Isoelectric Point: 6.4701

>AT55194 WP_034201144.1 NZ_CP011917:c2907259-2907023 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT55194 NZ_CP011917:c2907259-2907023 [Burkholderia cenocepacia]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATTGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACCCAGGTACTGGCGA
AGTTCGCGAAATTCGGACCGGACTTCATGGCCGATGGGCGTGGCGACCACGAGCAGGCCGAACGTGAGGGTTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A364GPY9