Detailed information of TA system TA055164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 107301..108121
• Replicon: chromosome
• Accession: NZ_CP011915
• Organism: Escherichia coli strain PSUO2

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: ACJ74_RS00570
• Protein ID: WP_001054376.1
• Coordinates: 107301..107558 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: ACJ74_RS00575
• Protein ID: WP_001519303.1
• Coordinates: 107570..108121 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACJ74_RS00540	102587..103693	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
ACJ74_RS00545	103758..104738	+	981	WP_001519307.1	transposase	-
ACJ74_RS00555	105321..106562	-	1242	Protein_100	helicase YjhR	-
ACJ74_RS00560	106625..106924	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
ACJ74_RS00570	107301..107558	+	258	WP_001054376.1	hypothetical protein	Toxin
ACJ74_RS00575	107570..108121	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
ACJ74_RS26235	108173..108334	+	162	WP_001519302.1	hypothetical protein	-
ACJ74_RS00580	108371..108919	+	549	WP_001519301.1	hypothetical protein	-
ACJ74_RS00585	109046..109306	+	261	WP_000084876.1	hypothetical protein	-
ACJ74_RS26240	109344..109460	+	117	Protein_107	VOC family protein	-
ACJ74_RS00595	109705..110826	+	1122	WP_000010833.1	M42 family metallopeptidase	-
ACJ74_RS00600	110823..111101	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
ACJ74_RS00605	111113..112426	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	96316..116341	20025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T55164 WP_001054376.1 NZ_CP011915:107301-107558 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T55164 NZ_CP011915:107301-107558 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT55164 WP_001519303.1 NZ_CP011915:107570-108121 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT55164 NZ_CP011915:107570-108121 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: S1PA82