Detailed information of TA system TA055159

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2833109..2833754
• Replicon: chromosome
• Accession: NZ_CP011883
• Organism: Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B586_RS13320
• Protein ID: WP_047315045.1
• Coordinates: 2833326..2833754 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B586_RS13315
• Protein ID: WP_054879696.1
• Coordinates: 2833109..2833342 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B586_RS13290	2829664..2830587	-	924	WP_054879698.1	DegV family protein	-
B586_RS13295	2830591..2831322	-	732	WP_054879697.1	SGNH/GDSL hydrolase family protein	-
B586_RS13300	2831312..2831983	-	672	WP_047315134.1	histidine phosphatase family protein	-
B586_RS13305	2831980..2832369	-	390	WP_047315047.1	ribosome silencing factor	-
B586_RS13310	2832366..2833028	-	663	WP_082129438.1	nicotinate-nucleotide adenylyltransferase	-
B586_RS13315	2833109..2833342	+	234	WP_054879696.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
B586_RS13320	2833326..2833754	+	429	WP_047315045.1	type II toxin-antitoxin system VapC family toxin	Toxin
B586_RS13325	2833833..2834879	+	1047	WP_054879695.1	class I SAM-dependent methyltransferase	-
B586_RS13330	2834911..2836356	-	1446	WP_054879694.1	VWA domain-containing protein	-
B586_RS13335	2836374..2837258	-	885	WP_047315042.1	MoxR family ATPase	-
B586_RS13340	2837306..2838565	-	1260	WP_047315041.1	glutamate-5-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-131)

Antitoxin

• SpoVT-AbrB domain (2-36)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15154.44 Da
• Isoelectric Point: 7.4706

>T55159 WP_047315045.1 NZ_CP011883:2833326-2833754 [Mycobacterium haemophilum DSM 44634]
MPLSASTPTSLVDTSVAVALVVADHDHHEDTFRALRGRRLGLAGHAAFETFSVLTRLPPPARRTPATIAKVLAQTFPETR
FLGTRAATALLAQLETAEIAGGAIYDALVGATAMEHQLTLVTRDRRAVEVYRTLGVAIELLA

Nucleotide

• Length: 429 bp

>T55159 NZ_CP011883:2833326-2833754 [Mycobacterium haemophilum DSM 44634]
ATGCCGCTCAGCGCTAGCACACCCACATCACTCGTGGACACCAGCGTCGCCGTCGCACTGGTAGTCGCCGATCACGACCA
CCACGAGGACACCTTCCGAGCGTTACGCGGCCGGAGATTGGGTCTGGCCGGCCACGCCGCATTTGAGACGTTCTCTGTCC
TGACCCGCCTGCCGCCGCCGGCCCGCAGGACTCCGGCGACCATCGCGAAGGTACTGGCACAAACCTTTCCGGAGACCAGG
TTTCTCGGGACTCGCGCCGCCACTGCACTACTGGCACAGCTCGAAACGGCCGAGATCGCCGGTGGCGCAATCTATGACGC
CCTAGTCGGCGCCACGGCCATGGAACATCAACTCACCCTAGTGACTCGTGATCGGCGAGCAGTGGAGGTCTACCGCACCC
TCGGCGTGGCCATCGAACTGCTGGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8132.27 Da
• Isoelectric Point: 4.7527

>AT55159 WP_054879696.1 NZ_CP011883:2833109-2833342 [Mycobacterium haemophilum DSM 44634]
MRATIDKAGRLVIPKPLRDHLGLQPGEVEVTADGAGLRMEPLAGDSLDEREGRFVIPAGGAEITDAVVATLRDAAQR

Nucleotide

• Length: 234 bp

>AT55159 NZ_CP011883:2833109-2833342 [Mycobacterium haemophilum DSM 44634]
ATGCGTGCAACCATTGATAAGGCAGGCAGATTGGTTATCCCGAAGCCGCTACGCGACCATCTCGGGCTGCAACCGGGCGA
GGTCGAAGTGACCGCTGACGGCGCTGGACTGCGCATGGAGCCGCTGGCCGGTGACTCTCTCGACGAGCGGGAGGGGCGCT
TTGTGATACCGGCAGGCGGGGCGGAAATCACCGACGCGGTCGTCGCGACATTGCGCGATGCCGCTCAGCGCTAG