Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2391153..2391800 Replicon chromosome
Accession NZ_CP011883
Organism Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)


Gene name vapC Uniprot ID A0A0I9U7K6
Locus tag B586_RS11260 Protein ID WP_047314064.1
Coordinates 2391153..2391569 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0I9TUR5
Locus tag B586_RS11265 Protein ID WP_047314063.1
Coordinates 2391579..2391800 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B586_RS11220 2386891..2387319 + 429 WP_054879924.1 cellulose-binding domain-containing protein -
B586_RS11225 2387890..2388126 + 237 WP_047314069.1 ribbon-helix-helix protein, CopG family -
B586_RS11230 2388126..2388560 + 435 WP_054879923.1 type II toxin-antitoxin system VapC family toxin -
B586_RS11235 2389030..2389263 + 234 WP_047314067.1 hypothetical protein -
B586_RS11240 2389260..2389595 + 336 WP_047314219.1 type II toxin-antitoxin system PemK/MazF family toxin -
B586_RS20145 2389777..2390460 - 684 Protein_2265 hypothetical protein -
B586_RS11260 2391153..2391569 - 417 WP_047314064.1 ribonuclease Toxin
B586_RS11265 2391579..2391800 - 222 WP_047314063.1 hypothetical protein Antitoxin
B586_RS11270 2392396..2394015 - 1620 WP_082607592.1 acyl--CoA ligase -
B586_RS11275 2394037..2395704 - 1668 WP_054879918.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-136)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15169.40 Da        Isoelectric Point: 6.3704

>T55158 WP_047314064.1 NZ_CP011883:c2391569-2391153 [Mycobacterium haemophilum DSM 44634]
MALLDVNSLIALAWDSHIHHVRMREWFAANAPQGWATCPITESGFVRVSTNPKVLPSPIGMSDAQHVLISLRGADGHQFL
FDDVSITDDDVPTILGHRQVTDAHLLTLARRRGVRLVTFDAAIVSLAQGRDVELLTLL

Download         Length: 417 bp

>T55158 NZ_CP011883:c2391569-2391153 [Mycobacterium haemophilum DSM 44634]
ATGGCGCTGCTCGACGTCAACTCGCTGATCGCTTTGGCGTGGGACTCTCACATCCACCACGTACGTATGCGCGAGTGGTT
TGCCGCTAATGCGCCGCAGGGCTGGGCGACCTGCCCCATCACAGAAAGCGGGTTCGTTCGCGTGTCGACGAACCCGAAGG
TGCTTCCGAGTCCTATCGGGATGTCCGACGCGCAGCACGTTCTCATTTCCCTGCGTGGGGCTGATGGCCACCAGTTCCTA
TTCGACGACGTGTCAATTACTGATGACGACGTTCCAACTATTCTCGGTCACCGCCAAGTGACAGACGCGCATCTGCTCAC
GCTCGCGCGCCGTAGGGGAGTTCGCCTCGTTACGTTCGACGCCGCGATCGTTTCTCTCGCGCAGGGACGCGATGTGGAAC
TACTGACCTTGCTTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7713.80 Da        Isoelectric Point: 4.7247

>AT55158 WP_047314063.1 NZ_CP011883:c2391800-2391579 [Mycobacterium haemophilum DSM 44634]
MRTTLDLDDDVVVAARELAAGERRSLGAVISELARRGLTPARVEAAGGLPVVRVPPGTPPITPETVRRALDED

Download         Length: 222 bp

>AT55158 NZ_CP011883:c2391800-2391579 [Mycobacterium haemophilum DSM 44634]
ATGCGAACAACACTGGACCTCGATGATGACGTGGTCGTTGCGGCACGCGAACTGGCCGCTGGTGAGCGGCGTTCCTTGGG
TGCGGTGATCTCCGAGCTGGCGCGCCGCGGCCTCACGCCGGCGCGTGTTGAGGCCGCCGGTGGGTTGCCGGTCGTCCGTG
TGCCACCGGGTACGCCACCGATCACGCCCGAAACCGTCCGACGTGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0I9U7K6

Antitoxin

Source ID Structure
AlphaFold DB A0A0I9TUR5

References