Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1256060..1256721 Replicon chromosome
Accession NZ_CP011883
Organism Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)


Gene name vapC Uniprot ID A0A0I9TUJ8
Locus tag B586_RS06025 Protein ID WP_047313157.1
Coordinates 1256060..1256476 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0I9VIH6
Locus tag B586_RS06030 Protein ID WP_047313156.1
Coordinates 1256473..1256721 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B586_RS06005 1251443..1251979 - 537 WP_047313455.1 YceI family protein -
B586_RS06010 1252103..1253074 - 972 WP_054880433.1 NADPH:quinone oxidoreductase family protein -
B586_RS06015 1253163..1254365 - 1203 WP_047313159.1 acyl-CoA dehydrogenase family protein -
B586_RS06020 1254407..1255816 - 1410 WP_054880432.1 acyl-CoA/acyl-ACP dehydrogenase -
B586_RS06025 1256060..1256476 - 417 WP_047313157.1 type II toxin-antitoxin system VapC family toxin Toxin
B586_RS06030 1256473..1256721 - 249 WP_047313156.1 toxin-antitoxin system Antitoxin
B586_RS06035 1256999..1257784 - 786 WP_054880431.1 histidinol-phosphatase -
B586_RS06040 1257873..1258220 + 348 WP_054880430.1 hypothetical protein -
B586_RS06045 1258451..1259155 - 705 WP_054880429.1 indole-3-glycerol-phosphate synthase -
B586_RS06050 1259440..1260510 + 1071 WP_054880428.1 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15353.54 Da        Isoelectric Point: 8.9285

>T55157 WP_047313157.1 NZ_CP011883:c1256476-1256060 [Mycobacterium haemophilum DSM 44634]
MILLDTNVLSALMLNTPDPAAVKWLDNQPAESIWTTSITVFEIRTGIDLLERGRRRTQLDRAFSQLLEEDLNGRIQSFEQ
TAALAAGTIAASRQRMGRVVEIRDVQIAGIATARHATVATRNTRHFEGTGVKLVDPWK

Download         Length: 417 bp

>T55157 NZ_CP011883:c1256476-1256060 [Mycobacterium haemophilum DSM 44634]
ATGATCTTGCTCGATACCAATGTGCTCTCCGCCCTGATGCTGAACACCCCTGATCCGGCCGCGGTAAAGTGGCTCGATAA
TCAGCCGGCGGAATCAATCTGGACGACATCGATCACCGTCTTCGAAATACGGACTGGGATAGATCTTTTGGAGCGCGGTC
GGCGCCGCACACAGCTTGATCGGGCGTTTTCCCAACTCCTGGAAGAAGACCTCAACGGGCGCATTCAGTCGTTCGAGCAG
ACAGCCGCCCTCGCTGCTGGGACTATCGCTGCAAGCCGGCAACGTATGGGACGCGTGGTGGAGATTCGCGACGTCCAGAT
CGCCGGAATCGCCACAGCCCGCCATGCCACCGTGGCCACCCGCAACACCCGACACTTCGAAGGAACCGGCGTCAAGCTCG
TCGATCCATGGAAATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9231.38 Da        Isoelectric Point: 9.0148

>AT55157 WP_047313156.1 NZ_CP011883:c1256721-1256473 [Mycobacterium haemophilum DSM 44634]
MAQILIRQLDDDTKSKLHRLARQHGRSTEEEVREILRNAVRTVDNPPGRLGSRIASRFTGAGLTDEIPELRGQPVQPAQF
ES

Download         Length: 249 bp

>AT55157 NZ_CP011883:c1256721-1256473 [Mycobacterium haemophilum DSM 44634]
ATGGCGCAGATTCTGATCCGGCAACTCGATGACGACACCAAATCCAAGTTGCACCGCCTAGCCCGCCAACACGGTCGCAG
TACGGAGGAAGAAGTACGGGAGATCCTGCGAAACGCCGTCCGCACCGTTGATAACCCACCTGGTCGACTGGGTTCCCGGA
TCGCCTCGCGTTTCACCGGCGCTGGTCTGACGGACGAGATCCCCGAACTGCGGGGCCAGCCTGTGCAACCGGCGCAGTTC
GAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0I9TUJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0I9VIH6

References