55155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 356792..357524 Replicon chromosome
Accession NZ_CP011883
Organism Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)


Gene name vapC Uniprot ID A0A0I9UYJ0
Locus tag B586_RS01645 Protein ID WP_047315901.1
Coordinates 356792..357253 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0I9V0M0
Locus tag B586_RS01650 Protein ID WP_047315902.1
Coordinates 357264..357524 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B586_RS19755 352063..352375 - 313 Protein_328 acyl-CoA/acyl-ACP dehydrogenase -
B586_RS01615 352400..353533 - 1134 WP_054878883.1 alpha/beta hydrolase -
B586_RS01620 353554..353844 - 291 Protein_330 TetR/AcrR family transcriptional regulator -
B586_RS01625 353998..354582 + 585 WP_047315897.1 VOC family protein -
B586_RS01630 354582..355130 + 549 WP_047315898.1 hypothetical protein -
B586_RS01635 355063..355791 - 729 WP_054878882.1 TetR/AcrR family transcriptional regulator -
B586_RS01640 355875..356795 + 921 WP_054878881.1 DUF2236 domain-containing protein -
B586_RS01645 356792..357253 - 462 WP_047315901.1 type II toxin-antitoxin system VapC family toxin Toxin
B586_RS01650 357264..357524 - 261 WP_047315902.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B586_RS01655 357719..358627 + 909 WP_047315937.1 class I SAM-dependent methyltransferase -
B586_RS01660 358763..360355 + 1593 WP_082607473.1 PPE family protein -
B586_RS01665 360483..362402 + 1920 WP_047315904.1 type VII secretion AAA-ATPase EccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16368.49 Da        Isoelectric Point: 6.3695

>T55155 WP_047315901.1 NZ_CP011883:c357253-356792 [Mycobacterium haemophilum DSM 44634]
MIIDTSAIVALIQDEQPHTGQVVAALAGARSPVMSAPTVAECLIVLTARHGPVGRTIFERLRSEINLGVEPFTYDHATAA
QRAFLQYGKGRHPAALNFGDCMSYAAAQLSHQPLLAVGNDFAQTDLEFSGVIGHWPTPNETSSASGAHKRYLD

Download         Length: 462 bp

>T55155 NZ_CP011883:c357253-356792 [Mycobacterium haemophilum DSM 44634]
ATGATCATCGACACCAGCGCGATCGTGGCCCTGATTCAAGACGAGCAACCCCATACCGGGCAGGTTGTGGCCGCGCTGGC
CGGTGCTCGTAGCCCGGTCATGTCGGCCCCAACCGTTGCTGAATGCCTCATCGTCCTAACAGCACGCCACGGGCCGGTGG
GACGCACCATCTTTGAACGCCTGCGCAGCGAAATCAACTTGGGTGTAGAGCCTTTCACCTATGACCATGCGACCGCCGCG
CAACGGGCCTTCCTGCAGTACGGCAAGGGCCGTCATCCCGCAGCCCTTAACTTCGGGGACTGTATGAGCTACGCGGCCGC
GCAACTGAGTCACCAACCACTGCTGGCCGTAGGCAATGACTTCGCCCAAACCGACCTCGAGTTCAGCGGCGTTATCGGCC
ACTGGCCCACACCAAACGAGACATCGTCGGCAAGCGGCGCCCACAAGCGCTACCTCGACTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9696.10 Da        Isoelectric Point: 6.4811

>AT55155 WP_047315902.1 NZ_CP011883:c357524-357264 [Mycobacterium haemophilum DSM 44634]
MALNIKDPEVDRLAAEMANRLHTTKTAAIRHALHAQLALLGSRADDRQTQLLDVMRTEIWPLLTDHTPIAKREREEILGY
DPTTGV

Download         Length: 261 bp

>AT55155 NZ_CP011883:c357524-357264 [Mycobacterium haemophilum DSM 44634]
ATGGCACTGAACATCAAGGATCCCGAGGTAGACCGGCTTGCCGCCGAAATGGCCAATCGGCTGCACACCACTAAAACTGC
CGCTATCCGCCACGCCCTGCACGCCCAGCTGGCGCTTCTGGGATCGCGCGCGGACGACCGTCAGACACAGCTCCTCGACG
TCATGCGCACCGAAATCTGGCCGCTACTCACGGACCACACCCCCATCGCCAAACGCGAACGCGAGGAAATTCTTGGCTAC
GACCCCACAACGGGAGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0I9UYJ0

Antitoxin

Source ID Structure
AlphaFold DB A0A0I9V0M0

References