Detailed information of TA system TA055154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 126627..127252
• Replicon: chromosome
• Accession: NZ_CP011883
• Organism: Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B586_RS00630
• Protein ID: WP_054880789.1
• Coordinates: 126872..127252 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B586_RS00625
• Protein ID: WP_054878991.1
• Coordinates: 126627..126875 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B586_RS00600	121758..123041	+	1284	WP_082607462.1	MmgE/PrpD family protein	-
B586_RS00610	123772..124347	+	576	WP_054878994.1	PPE family protein	-
B586_RS19680	124921..125091	+	171	WP_082607463.1	PPE domain-containing protein	-
B586_RS00615	125084..125326	+	243	WP_054878993.1	PPE domain-containing protein	-
B586_RS00620	125778..126542	+	765	WP_054878992.1	DUF2127 domain-containing protein	-
B586_RS00625	126627..126875	+	249	WP_054878991.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
B586_RS00630	126872..127252	+	381	WP_054880789.1	type II toxin-antitoxin system VapC family toxin	Toxin
B586_RS20620	128235..128390	+	156	WP_156166412.1	hypothetical protein	-
B586_RS21535	128612..128755	-	144	WP_211141546.1	hypothetical protein	-
B586_RS00645	128959..129429	+	471	WP_047314545.1	SRPBCC family protein	-
B586_RS00650	129487..130293	+	807	WP_054878990.1	SDR family NAD(P)-dependent oxidoreductase	-
B586_RS00655	130307..131044	-	738	WP_054878989.1	methyltransferase domain-containing protein	-
B586_RS20625	131068..131167	-	100	Protein_130	sirohydrochlorin chelatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-112)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-70)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13528.66 Da
• Isoelectric Point: 6.4693

>T55154 WP_054880789.1 NZ_CP011883:126872-127252 [Mycobacterium haemophilum DSM 44634]
VRAILDTSVVIATDIAPLEGELGISAITLAELNFGVLVAKQRKVRAERLRRLLALQRIFDALPLDDAVAASYGQLAAAVV
DAGRQPRARSMDLLIAATAHAHSARLYTRNIDDFAGLDDLVDVVKV

Nucleotide

• Length: 381 bp

>T55154 NZ_CP011883:126872-127252 [Mycobacterium haemophilum DSM 44634]
GTGAGGGCGATTCTCGACACCAGCGTGGTCATCGCGACGGACATCGCGCCCCTCGAAGGCGAGTTGGGCATAAGCGCAAT
CACATTGGCGGAACTTAACTTTGGTGTTCTAGTCGCGAAGCAACGAAAGGTGCGTGCCGAGCGGCTCCGACGTCTGCTGG
CGCTTCAGCGCATATTCGATGCGCTGCCCCTGGATGACGCCGTGGCAGCTAGCTATGGTCAGCTGGCGGCAGCCGTCGTC
GACGCGGGACGTCAGCCGCGAGCACGATCGATGGACCTGCTGATCGCGGCCACCGCCCACGCCCATTCGGCCCGGCTCTA
CACCCGCAACATCGATGACTTCGCCGGCCTCGACGACCTGGTCGACGTCGTCAAGGTCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8993.03 Da
• Isoelectric Point: 4.3322

>AT55154 WP_054878991.1 NZ_CP011883:126627-126875 [Mycobacterium haemophilum DSM 44634]
VAVVGLRELRQNASDLVRRVEEGEEITVTVAGRPGARLVPAASRIWRQWAELAELFAGPADPAWDADRGAIADDVRDPWT
TE

Nucleotide

• Length: 249 bp

>AT55154 NZ_CP011883:126627-126875 [Mycobacterium haemophilum DSM 44634]
GTGGCAGTTGTTGGATTGCGCGAGCTGCGTCAGAACGCCTCCGACCTTGTTCGGCGCGTCGAAGAAGGTGAGGAAATCAC
CGTCACCGTGGCCGGCCGACCGGGAGCGCGGCTGGTGCCTGCGGCCTCTCGAATCTGGAGACAGTGGGCCGAGCTGGCCG
AACTGTTTGCTGGTCCCGCAGATCCTGCCTGGGATGCCGACCGCGGGGCAATCGCAGATGACGTACGCGACCCGTGGACG
ACGGAGTGA