Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 126627..127252 Replicon chromosome
Accession NZ_CP011883
Organism Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B586_RS00630 Protein ID WP_054880789.1
Coordinates 126872..127252 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B586_RS00625 Protein ID WP_054878991.1
Coordinates 126627..126875 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B586_RS00600 121758..123041 + 1284 WP_082607462.1 MmgE/PrpD family protein -
B586_RS00610 123772..124347 + 576 WP_054878994.1 PPE family protein -
B586_RS19680 124921..125091 + 171 WP_082607463.1 PPE domain-containing protein -
B586_RS00615 125084..125326 + 243 WP_054878993.1 PPE domain-containing protein -
B586_RS00620 125778..126542 + 765 WP_054878992.1 DUF2127 domain-containing protein -
B586_RS00625 126627..126875 + 249 WP_054878991.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
B586_RS00630 126872..127252 + 381 WP_054880789.1 type II toxin-antitoxin system VapC family toxin Toxin
B586_RS20620 128235..128390 + 156 WP_156166412.1 hypothetical protein -
B586_RS21535 128612..128755 - 144 WP_211141546.1 hypothetical protein -
B586_RS00645 128959..129429 + 471 WP_047314545.1 SRPBCC family protein -
B586_RS00650 129487..130293 + 807 WP_054878990.1 SDR family NAD(P)-dependent oxidoreductase -
B586_RS00655 130307..131044 - 738 WP_054878989.1 methyltransferase domain-containing protein -
B586_RS20625 131068..131167 - 100 Protein_130 sirohydrochlorin chelatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-112)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-70)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13528.66 Da        Isoelectric Point: 6.4693

>T55154 WP_054880789.1 NZ_CP011883:126872-127252 [Mycobacterium haemophilum DSM 44634]
VRAILDTSVVIATDIAPLEGELGISAITLAELNFGVLVAKQRKVRAERLRRLLALQRIFDALPLDDAVAASYGQLAAAVV
DAGRQPRARSMDLLIAATAHAHSARLYTRNIDDFAGLDDLVDVVKV

Download         Length: 381 bp

>T55154 NZ_CP011883:126872-127252 [Mycobacterium haemophilum DSM 44634]
GTGAGGGCGATTCTCGACACCAGCGTGGTCATCGCGACGGACATCGCGCCCCTCGAAGGCGAGTTGGGCATAAGCGCAAT
CACATTGGCGGAACTTAACTTTGGTGTTCTAGTCGCGAAGCAACGAAAGGTGCGTGCCGAGCGGCTCCGACGTCTGCTGG
CGCTTCAGCGCATATTCGATGCGCTGCCCCTGGATGACGCCGTGGCAGCTAGCTATGGTCAGCTGGCGGCAGCCGTCGTC
GACGCGGGACGTCAGCCGCGAGCACGATCGATGGACCTGCTGATCGCGGCCACCGCCCACGCCCATTCGGCCCGGCTCTA
CACCCGCAACATCGATGACTTCGCCGGCCTCGACGACCTGGTCGACGTCGTCAAGGTCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8993.03 Da        Isoelectric Point: 4.3322

>AT55154 WP_054878991.1 NZ_CP011883:126627-126875 [Mycobacterium haemophilum DSM 44634]
VAVVGLRELRQNASDLVRRVEEGEEITVTVAGRPGARLVPAASRIWRQWAELAELFAGPADPAWDADRGAIADDVRDPWT
TE

Download         Length: 249 bp

>AT55154 NZ_CP011883:126627-126875 [Mycobacterium haemophilum DSM 44634]
GTGGCAGTTGTTGGATTGCGCGAGCTGCGTCAGAACGCCTCCGACCTTGTTCGGCGCGTCGAAGAAGGTGAGGAAATCAC
CGTCACCGTGGCCGGCCGACCGGGAGCGCGGCTGGTGCCTGCGGCCTCTCGAATCTGGAGACAGTGGGCCGAGCTGGCCG
AACTGTTTGCTGGTCCCGCAGATCCTGCCTGGGATGCCGACCGCGGGGCAATCGCAGATGACGTACGCGACCCGTGGACG
ACGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References