Detailed information of TA system TA055153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK(toxin)
• Location: 84543..85116
• Replicon: chromosome
• Accession: NZ_CP011883
• Organism: Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: B586_RS00405
• Protein ID: WP_054879017.1
• Coordinates: 84543..84887 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A0I9XFS8
• Locus tag: B586_RS00410
• Protein ID: WP_047316812.1
• Coordinates: 84880..85116 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B586_RS00390	80481..81293	+	813	WP_047316804.1	methyltransferase domain-containing protein	-
B586_RS00395	82172..83413	-	1242	WP_054879018.1	MFS transporter	-
B586_RS00400	83501..84172	+	672	WP_047316810.1	FadR family transcriptional regulator	-
B586_RS00405	84543..84887	-	345	WP_054879017.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
B586_RS00410	84880..85116	-	237	WP_047316812.1	hypothetical protein	Antitoxin
B586_RS00415	85415..86092	-	678	WP_054879016.1	thioredoxin domain-containing protein	-
B586_RS00420	86325..86882	-	558	WP_052915752.1	PPE family protein	-
B586_RS00425	86965..87264	-	300	WP_047316807.1	PE family protein	-
B586_RS00430	87489..88667	-	1179	WP_082607702.1	CoA transferase	-
B586_RS00435	88928..89752	-	825	WP_047316921.1	cyclase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12244.43 Da
• Isoelectric Point: 11.5351

>T55153 WP_054879017.1 NZ_CP011883:c84887-84543 [Mycobacterium haemophilum DSM 44634]
MSDPRRGELWLVALGAGRAGEPAKHRPAAVVSVDDILSGLESELVVVVPVSRSRTLSPLRPRITAMEGVEVDSVAVCRAV
RGITKSRLVRPLGKLRPNTMREVERALAMVLGIA

Nucleotide

• Length: 345 bp

>T55153 NZ_CP011883:c84887-84543 [Mycobacterium haemophilum DSM 44634]
TTGAGTGATCCACGGCGCGGAGAACTTTGGCTGGTCGCACTCGGCGCGGGACGCGCCGGGGAACCGGCGAAGCACCGGCC
GGCCGCGGTGGTCTCTGTCGACGACATCCTCTCCGGCCTTGAATCGGAACTCGTTGTAGTTGTGCCTGTTTCACGTTCGC
GCACGTTGTCGCCATTGCGGCCCCGCATCACCGCAATGGAGGGAGTCGAGGTGGATAGTGTCGCTGTGTGTCGGGCAGTG
CGCGGGATCACCAAAAGTCGGCTGGTCCGGCCGCTGGGCAAGTTGAGGCCGAACACGATGCGCGAGGTCGAGCGCGCTCT
AGCCATGGTTCTCGGAATCGCCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8472.35 Da
• Isoelectric Point: 3.8852

>AT55153 WP_047316812.1 NZ_CP011883:c85116-84880 [Mycobacterium haemophilum DSM 44634]
MATGTTTIRVPLPTRDRLAAQARQRGISIAALLEELSDQAERQAAFEAERMATLADAEMPEVQDEDLDWDATAGDGIE

Nucleotide

• Length: 237 bp

>AT55153 NZ_CP011883:c85116-84880 [Mycobacterium haemophilum DSM 44634]
ATGGCTACTGGTACGACGACGATTCGGGTGCCTCTCCCAACCCGCGACAGGCTCGCCGCGCAAGCTCGCCAGCGCGGCAT
CTCAATCGCAGCTCTCCTCGAGGAACTGTCTGACCAGGCCGAACGGCAGGCCGCGTTCGAGGCTGAGCGCATGGCCACCC
TGGCCGACGCAGAAATGCCCGAGGTCCAGGACGAGGACCTGGACTGGGACGCCACCGCAGGTGACGGCATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0I9XFS8