55143

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4610117..4610784 Replicon chromosome
Accession NZ_CP011863
Organism Enterobacter asburiae strain ATCC 35953

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag ACJ69_RS22495 Protein ID WP_047358936.1
Coordinates 4610117..4610446 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag ACJ69_RS22500 Protein ID WP_047358935.1
Coordinates 4610467..4610784 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACJ69_RS22455 4605147..4605551 + 405 WP_032660403.1 DNA-binding protein StpA -
ACJ69_RS22460 4605590..4605769 - 180 WP_023308920.1 hypothetical protein -
ACJ69_RS22465 4605849..4606370 - 522 WP_059347771.1 rhodanese family protein -
ACJ69_RS22470 4606380..4606679 - 300 WP_029742056.1 metalloregulator ArsR/SmtB family transcription factor -
ACJ69_RS22475 4606859..4607017 + 159 WP_023308917.1 YqaE/Pmp3 family membrane protein -
ACJ69_RS22480 4607014..4607943 - 930 WP_029742057.1 LysR family transcriptional regulator -
ACJ69_RS22485 4608226..4608923 + 698 Protein_4403 IS1 family transposase -
ACJ69_RS22490 4608951..4609748 - 798 Protein_4404 integrase arm-type DNA-binding domain-containing protein -
ACJ69_RS22495 4610117..4610446 - 330 WP_047358936.1 TA system toxin CbtA family protein Toxin
ACJ69_RS22500 4610467..4610784 - 318 WP_047358935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ACJ69_RS22505 4610803..4611024 - 222 WP_047358934.1 DUF987 domain-containing protein -
ACJ69_RS22510 4611033..4611515 - 483 WP_032238502.1 DNA repair protein RadC -
ACJ69_RS22515 4611524..4611976 - 453 WP_047358933.1 antirestriction protein -
ACJ69_RS22520 4612062..4612298 - 237 WP_047358932.1 DUF905 domain-containing protein -
ACJ69_RS22525 4612376..4612786 - 411 WP_047358931.1 hypothetical protein -
ACJ69_RS22530 4612851..4613288 - 438 WP_038434461.1 hypothetical protein -
ACJ69_RS22535 4613330..4613866 - 537 WP_047358930.1 DUF4339 domain-containing protein -
ACJ69_RS22540 4613892..4614602 - 711 WP_047358929.1 DeoR family transcriptional regulator -
ACJ69_RS22545 4614811..4615635 - 825 WP_047358928.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4595759..4620114 24355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12344.43 Da        Isoelectric Point: 9.5732

>T55143 WP_047358936.1 NZ_CP011863:c4610446-4610117 [Enterobacter asburiae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSSGLLKTNVK

Download         Length: 330 bp

>T55143 NZ_CP011863:c4610446-4610117 [Enterobacter asburiae]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCTGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGTATCGACCGAAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATCTTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTAGCGGCTTGCTAAAAACTAA
CGTGAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11837.43 Da        Isoelectric Point: 6.8407

>AT55143 WP_047358935.1 NZ_CP011863:c4610784-4610467 [Enterobacter asburiae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECFKLDVAFPHFISQMESMLTTGEMNPRHARCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT55143 NZ_CP011863:c4610784-4610467 [Enterobacter asburiae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGATGCCGAATGTTTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCGCTGTGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References