Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4345281..4345938 Replicon chromosome
Accession NZ_CP011863
Organism Enterobacter asburiae strain ATCC 35953

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag ACJ69_RS21105 Protein ID WP_021242050.1
Coordinates 4345528..4345938 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag ACJ69_RS21100 Protein ID WP_010435322.1
Coordinates 4345281..4345547 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACJ69_RS21070 4340461..4341894 - 1434 WP_059347708.1 6-phospho-beta-glucosidase BglA -
ACJ69_RS21075 4342011..4342742 - 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
ACJ69_RS21080 4342794..4343105 + 312 WP_054830213.1 N(4)-acetylcytidine aminohydrolase -
ACJ69_RS21090 4343271..4343930 + 660 WP_023309101.1 hemolysin III family protein -
ACJ69_RS21095 4344006..4344986 - 981 WP_054830214.1 tRNA-modifying protein YgfZ -
ACJ69_RS21100 4345281..4345547 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
ACJ69_RS21105 4345528..4345938 + 411 WP_021242050.1 protein YgfX Toxin
ACJ69_RS21110 4345945..4346466 - 522 WP_059347709.1 flavodoxin FldB -
ACJ69_RS21115 4346568..4347464 + 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
ACJ69_RS21120 4347493..4348206 + 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ACJ69_RS21125 4348212..4349945 + 1734 WP_059347710.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T55142 WP_021242050.1 NZ_CP011863:4345528-4345938 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T55142 NZ_CP011863:4345528-4345938 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCTCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCAGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT55142 WP_010435322.1 NZ_CP011863:4345281-4345547 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT55142 NZ_CP011863:4345281-4345547 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TGTTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References