Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5134307..5134915 Replicon chromosome
Accession NZ_CP011857
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag ACG06_RS23940 Protein ID WP_003123043.1
Coordinates 5134307..5134654 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag ACG06_RS23945 Protein ID WP_003114155.1
Coordinates 5134664..5134915 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACG06_RS23920 5130583..5131815 + 1233 WP_016852057.1 phosphoadenosine phosphosulfate reductase family protein -
ACG06_RS33255 5131826..5132002 + 177 WP_016852058.1 hypothetical protein -
ACG06_RS23925 5131999..5132367 + 369 WP_016852059.1 ASCH domain-containing protein -
ACG06_RS32725 5132560..5132763 + 204 WP_003098423.1 AlpA family phage regulatory protein -
ACG06_RS23935 5132770..5133972 - 1203 WP_016852061.1 integrase family protein -
ACG06_RS23940 5134307..5134654 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACG06_RS23945 5134664..5134915 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ACG06_RS23950 5135129..5136112 - 984 WP_016852062.1 tyrosine-type recombinase/integrase -
ACG06_RS23955 5136112..5137404 - 1293 WP_003115206.1 hypothetical protein -
ACG06_RS23960 5137663..5138925 - 1263 WP_023093179.1 hypothetical protein -
ACG06_RS23965 5138927..5139277 - 351 WP_003159569.1 DUF2523 domain-containing protein -
ACG06_RS23970 5139287..5139892 - 606 WP_014603242.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5010775..5146238 135463


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T55126 WP_003123043.1 NZ_CP011857:c5134654-5134307 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T55126 NZ_CP011857:c5134654-5134307 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT55126 WP_003114155.1 NZ_CP011857:c5134915-5134664 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT55126 NZ_CP011857:c5134915-5134664 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References