55123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2691352..2692394 Replicon chromosome
Accession NZ_CP011857
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag ACG06_RS12920 Protein ID WP_003153636.1
Coordinates 2691819..2692394 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag ACG06_RS12915 Protein ID WP_003050245.1
Coordinates 2691352..2691822 (+) Length 157 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACG06_RS12880 2686744..2688162 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
ACG06_RS12885 2688152..2689063 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
ACG06_RS12890 2689060..2689752 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
ACG06_RS12895 2689749..2690147 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
ACG06_RS12900 2690159..2690518 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
ACG06_RS12905 2690535..2690768 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
ACG06_RS12910 2690765..2691148 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
ACG06_RS12915 2691352..2691822 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
ACG06_RS12920 2691819..2692394 + 576 WP_003153636.1 PIN domain-containing protein Toxin
ACG06_RS12925 2692412..2693326 + 915 WP_016852809.1 AAA family ATPase -
ACG06_RS12930 2693323..2693793 + 471 WP_003090160.1 hypothetical protein -
ACG06_RS12935 2693790..2694290 + 501 WP_003090159.1 hypothetical protein -
ACG06_RS12940 2694290..2695192 + 903 WP_003090158.1 nucleotidyltransferase domain-containing protein -
ACG06_RS12945 2695231..2695956 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2616788..2738492 121704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-114)

Antitoxin

(85-133)


Sequences


Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T55123 WP_003153636.1 NZ_CP011857:2691819-2692394 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T55123 NZ_CP011857:2691819-2692394 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAATGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT55123 WP_003050245.1 NZ_CP011857:2691352-2691822 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT55123 NZ_CP011857:2691352-2691822 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References