Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 148718..149223 Replicon chromosome
Accession NZ_CP011857
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag ACG06_RS00665 Protein ID WP_003121619.1
Coordinates 148718..148999 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag ACG06_RS00670 Protein ID WP_003112628.1
Coordinates 148996..149223 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACG06_RS00640 143969..145318 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
ACG06_RS00645 145367..146053 + 687 WP_003083762.1 FadR family transcriptional regulator -
ACG06_RS00650 146154..146888 + 735 WP_003117208.1 GntR family transcriptional regulator -
ACG06_RS00655 147092..147478 + 387 WP_014602345.1 aegerolysin family protein -
ACG06_RS00660 147510..148418 - 909 WP_016561475.1 LysR family transcriptional regulator -
ACG06_RS00665 148718..148999 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
ACG06_RS00670 148996..149223 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
ACG06_RS00675 149399..150019 - 621 WP_003101226.1 hypothetical protein -
ACG06_RS00680 150120..150620 + 501 WP_003112629.1 LEA type 2 family protein -
ACG06_RS00685 150693..151034 + 342 WP_003101229.1 alkylphosphonate utilization protein -
ACG06_RS00690 151116..152543 - 1428 WP_003083784.1 GABA permease -
ACG06_RS00695 152712..154205 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T55121 WP_003121619.1 NZ_CP011857:c148999-148718 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T55121 NZ_CP011857:c148999-148718 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT55121 WP_003112628.1 NZ_CP011857:c149223-148996 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT55121 NZ_CP011857:c149223-148996 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References