Detailed information of TA system TA055083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1715756..1716375
• Replicon: chromosome
• Accession: NZ_CP011835
• Organism: Azotobacter chroococcum strain B3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ACG10_RS07955
• Protein ID: WP_089167815.1
• Coordinates: 1715756..1715938 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ACG10_RS07960
• Protein ID: WP_089167816.1
• Coordinates: 1715968..1716375 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACG10_RS07925	1710934..1711269	-	336	WP_089167810.1	hypothetical protein	-
ACG10_RS07935	1711633..1711884	-	252	WP_089167812.1	hypothetical protein	-
ACG10_RS23600	1711881..1712036	-	156	WP_157731409.1	hypothetical protein	-
ACG10_RS07940	1712033..1712215	-	183	WP_039804029.1	hypothetical protein	-
ACG10_RS07945	1712199..1712561	-	363	WP_089167813.1	hypothetical protein	-
ACG10_RS07950	1715301..1715558	-	258	WP_089167814.1	DUF1654 domain-containing protein	-
ACG10_RS07955	1715756..1715938	+	183	WP_089167815.1	type II toxin-antitoxin system HicA family toxin	Toxin
ACG10_RS07960	1715968..1716375	+	408	WP_089167816.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ACG10_RS07965	1716402..1716653	-	252	WP_089167817.1	DUF1654 domain-containing protein	-
ACG10_RS07970	1716827..1717102	+	276	WP_089167818.1	hypothetical protein	-
ACG10_RS07975	1717554..1718555	-	1002	WP_089167819.1	hypothetical protein	-
ACG10_RS07980	1718621..1718875	-	255	WP_157731411.1	carbon storage regulator	-
ACG10_RS07985	1718820..1719722	-	903	WP_089167821.1	endonuclease	-
ACG10_RS07990	1719758..1720408	-	651	WP_089169815.1	XRE family transcriptional regulator	-
ACG10_RS07995	1720496..1720705	+	210	WP_089169816.1	helix-turn-helix domain-containing protein	-
ACG10_RS08000	1720815..1721237	+	423	WP_089167822.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1702601..1755478	52877

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6602.74 Da
• Isoelectric Point: 10.7162

>T55083 WP_089167815.1 NZ_CP011835:1715756-1715938 [Azotobacter chroococcum]
VNSREVIGLIEADGWYLVRVNGSHHHFKHPTKPGLVTIPHPKKDLLAKTVGSILKQAGIK

Nucleotide

• Length: 183 bp

>T55083 NZ_CP011835:1715756-1715938 [Azotobacter chroococcum]
GTGAATAGCCGTGAAGTAATAGGCCTCATTGAGGCGGACGGCTGGTATCTGGTGCGCGTGAATGGCAGTCATCACCACTT
CAAGCACCCGACCAAGCCTGGGCTGGTCACCATCCCGCACCCAAAGAAGGATCTGCTGGCCAAGACAGTCGGCAGCATCT
TGAAACAGGCCGGAATCAAGTAG

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14379.23 Da
• Isoelectric Point: 4.5885

>AT55083 WP_089167816.1 NZ_CP011835:1715968-1716375 [Azotobacter chroococcum]
MLYPIAISPGDEQHAWGVEVPDIPGCFSAGDNLDDAMAMAREAIEGHLELLAEEGAQIPEASSVTTHASNPDYAGCTWAV
VDIDVTRYMGKAEKLNITLPGHLLARIDAYVKAHPEQKSRSGFLAAAALKALQHG

Nucleotide

• Length: 408 bp

>AT55083 NZ_CP011835:1715968-1716375 [Azotobacter chroococcum]
ATGCTTTATCCAATTGCAATCTCACCCGGCGACGAGCAGCACGCCTGGGGCGTCGAAGTGCCGGACATCCCCGGCTGTTT
CTCTGCGGGCGATAACTTGGACGATGCGATGGCGATGGCTCGCGAGGCCATCGAGGGGCATCTGGAACTGTTAGCCGAAG
AGGGCGCGCAGATCCCCGAGGCGAGCAGTGTGACCACGCATGCGAGCAATCCGGACTACGCCGGTTGCACCTGGGCGGTG
GTAGACATCGATGTGACCCGGTACATGGGTAAGGCAGAGAAACTGAACATCACCCTGCCGGGGCACCTGCTGGCCCGGAT
CGATGCCTATGTGAAGGCCCATCCGGAGCAGAAGAGCCGCTCCGGCTTCCTGGCTGCCGCAGCATTGAAGGCGTTGCAGC
ACGGCTGA