Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 889853..890484 Replicon chromosome
Accession NZ_CP011834
Organism Limnohabitans sp. 103DPR2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L103DPR2_RS04350 Protein ID WP_197274931.1
Coordinates 889853..890248 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L103DPR2_RS04355 Protein ID WP_055359915.1
Coordinates 890251..890484 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L103DPR2_RS04325 885132..885995 - 864 WP_156339937.1 tryptophan 2,3-dioxygenase -
L103DPR2_RS04330 886052..887332 - 1281 WP_055359911.1 kynureninase -
L103DPR2_RS04335 887335..887961 - 627 WP_197274907.1 arylformamidase -
L103DPR2_RS04340 888069..888749 + 681 WP_055359912.1 molybdate ABC transporter permease subunit -
L103DPR2_RS04345 888746..889843 + 1098 WP_055359913.1 molybdenum ABC transporter ATP-binding protein -
L103DPR2_RS04350 889853..890248 - 396 WP_197274931.1 type II toxin-antitoxin system VapC family toxin Toxin
L103DPR2_RS04355 890251..890484 - 234 WP_055359915.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L103DPR2_RS04360 890692..891708 + 1017 WP_055359916.1 sulfate ABC transporter substrate-binding protein -
L103DPR2_RS04365 891862..892854 + 993 WP_082466854.1 sulfate ABC transporter substrate-binding protein -
L103DPR2_RS04370 892858..893724 + 867 WP_055359917.1 sulfate ABC transporter permease subunit CysT -
L103DPR2_RS04375 893721..894635 + 915 WP_055359918.1 sulfate ABC transporter permease subunit CysW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

SpoVT-AbrB domain

(7-36)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14448.77 Da        Isoelectric Point: 7.8166

>T55080 WP_197274931.1 NZ_CP011834:c890248-889853 [Limnohabitans sp. 103DPR2]
MLDTNTCIYIINNRPPNVLERFSKYKAGEVGISSIAASELAYGVAKSGSVKNRKALDLFLAPLQVLPFDSQCLWFYADLR
ASLEKQGLTIGAMDTLIAAHALSIDGTLVTNNLKEFARVPKLKLENWFEAI

Download         Length: 396 bp

>T55080 NZ_CP011834:c890248-889853 [Limnohabitans sp. 103DPR2]
TTGCTAGACACAAACACGTGCATCTACATCATCAACAATCGCCCCCCAAACGTACTCGAAAGATTCAGCAAGTACAAAGC
TGGCGAAGTCGGTATTAGCAGTATTGCCGCTTCAGAATTAGCTTATGGCGTCGCCAAATCAGGTTCTGTCAAGAATCGAA
AAGCGCTTGACCTGTTTTTGGCGCCATTGCAGGTCCTTCCGTTTGACAGTCAGTGTCTCTGGTTCTATGCAGATCTCAGA
GCCTCATTGGAAAAACAAGGCTTGACCATTGGCGCAATGGACACCTTGATCGCAGCACATGCACTGAGCATTGACGGCAC
ATTGGTGACCAACAACTTAAAAGAGTTTGCACGCGTACCCAAACTCAAACTTGAAAACTGGTTTGAGGCGATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8864.29 Da        Isoelectric Point: 7.0133

>AT55080 WP_055359915.1 NZ_CP011834:c890484-890251 [Limnohabitans sp. 103DPR2]
MDTAKIFQTGRSQAVRLPKEYRFNAKEVVIKRVGEGVLLMPIEDPWVTIEAALNAFESGFKIERQQPEHQIRPEVLL

Download         Length: 234 bp

>AT55080 NZ_CP011834:c890484-890251 [Limnohabitans sp. 103DPR2]
ATGGACACTGCCAAAATATTTCAAACGGGTCGCAGTCAGGCTGTTCGCCTTCCAAAGGAATACCGATTCAACGCCAAAGA
AGTTGTTATCAAACGTGTGGGTGAAGGCGTTTTATTGATGCCGATCGAAGATCCCTGGGTCACGATTGAAGCAGCATTGA
ACGCTTTCGAATCAGGCTTCAAAATTGAGCGGCAACAACCCGAACATCAAATTCGCCCTGAGGTTTTATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References