55078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2559836..2560365 Replicon chromosome
Accession NZ_CP011828
Organism Enterococcus faecium strain UW8175

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag UB18_RS12410 Protein ID WP_002294198.1
Coordinates 2559836..2560102 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag UB18_RS12415 Protein ID WP_002294199.1
Coordinates 2560102..2560365 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UB18_RS12385 2555203..2556378 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
UB18_RS12390 2556382..2557023 + 642 WP_002293405.1 ABC transporter permease -
UB18_RS12395 2557020..2557937 + 918 WP_002298332.1 osmoprotectant ABC transporter substrate-binding protein -
UB18_RS12400 2557934..2558605 + 672 WP_002319469.1 ABC transporter permease -
UB18_RS12405 2559147..2559635 - 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
UB18_RS12410 2559836..2560102 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
UB18_RS12415 2560102..2560365 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
UB18_RS12420 2560996..2562186 - 1191 WP_002298336.1 arabinan endo-1,5-alpha-L-arabinosidase -
UB18_RS12425 2562239..2562505 - 267 WP_002315578.1 hypothetical protein -
UB18_RS12430 2562510..2563955 - 1446 WP_002337067.1 alpha-N-arabinofuranosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T55078 WP_002294198.1 NZ_CP011828:c2560102-2559836 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T55078 NZ_CP011828:c2560102-2559836 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT55078 WP_002294199.1 NZ_CP011828:c2560365-2560102 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT55078 NZ_CP011828:c2560365-2560102 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGATGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References