55077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2259775..2260346 Replicon chromosome
Accession NZ_CP011828
Organism Enterococcus faecium strain UW8175

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag UB18_RS11035 Protein ID WP_002286801.1
Coordinates 2259775..2260116 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag UB18_RS11040 Protein ID WP_002323011.1
Coordinates 2260116..2260346 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UB18_RS11010 2254985..2256319 - 1335 WP_002286788.1 ABC transporter substrate-binding protein -
UB18_RS11015 2256527..2257357 + 831 WP_002286789.1 manganese catalase family protein -
UB18_RS14800 2257601..2257850 - 250 Protein_2111 transposase -
UB18_RS11025 2258041..2258235 - 195 WP_002297028.1 hypothetical protein -
UB18_RS11030 2258740..2258925 - 186 WP_002304207.1 hypothetical protein -
UB18_RS11035 2259775..2260116 - 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
UB18_RS11040 2260116..2260346 - 231 WP_002323011.1 hypothetical protein Antitoxin
UB18_RS11045 2260633..2260971 + 339 WP_002286804.1 hypothetical protein -
UB18_RS11050 2261176..2261415 - 240 WP_002321938.1 SOS response-associated peptidase family protein -
UB18_RS11055 2261391..2261738 - 348 WP_002286808.1 SOS response-associated peptidase family protein -
UB18_RS11060 2262470..2263051 - 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
UB18_RS11065 2263234..2263860 - 627 WP_002286816.1 cysteine hydrolase -
UB18_RS11070 2263882..2265213 - 1332 WP_002286818.1 FAD-containing oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T55077 WP_002286801.1 NZ_CP011828:c2260116-2259775 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

>T55077 NZ_CP011828:c2260116-2259775 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT55077 WP_002323011.1 NZ_CP011828:c2260346-2260116 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp

>AT55077 NZ_CP011828:c2260346-2260116 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References