Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5049049..5049716 Replicon chromosome
Accession NZ_CP011827
Organism Xanthomonas citri pv. citri strain jx-6

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag AB890_RS21670 Protein ID WP_005916679.1
Coordinates 5049300..5049716 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag AB890_RS21665 Protein ID WP_005916676.1
Coordinates 5049049..5049303 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB890_RS21640 5045171..5045390 + 220 Protein_4216 RNA 2'-phosphotransferase -
AB890_RS21645 5045547..5046812 + 1266 WP_015463799.1 cardiolipin synthase B -
AB890_RS21650 5046838..5047365 - 528 WP_005916668.1 hypothetical protein -
AB890_RS21655 5047604..5047810 + 207 WP_003489327.1 hypothetical protein -
AB890_RS21660 5047797..5048903 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
AB890_RS21665 5049049..5049303 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
AB890_RS21670 5049300..5049716 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
AB890_RS24920 5049838..5050041 - 204 WP_131830033.1 hypothetical protein -
AB890_RS24925 5050169..5050381 - 213 WP_015472901.1 hypothetical protein -
AB890_RS21675 5050638..5052257 + 1620 WP_015463800.1 hypothetical protein -
AB890_RS21680 5052361..5052759 - 399 WP_004429277.1 DUF2384 domain-containing protein -
AB890_RS21685 5053075..5053506 + 432 WP_005922907.1 hypothetical protein -
AB890_RS24160 5053535..5053861 - 327 Protein_4228 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T55076 WP_005916679.1 NZ_CP011827:5049300-5049716 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T55076 NZ_CP011827:5049300-5049716 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT55076 WP_005916676.1 NZ_CP011827:5049049-5049303 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT55076 NZ_CP011827:5049049-5049303 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References