55070

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 75227..75920 Replicon plasmid pPF72-2
Accession NZ_CP011809
Organism Pandoraea faecigallinarum strain DSM 23572

Toxin (Protein)


Gene name tad Uniprot ID A0A0H3X0K4
Locus tag AB870_RS25265 Protein ID WP_047909453.1
Coordinates 75227..75604 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0H3X3H3
Locus tag AB870_RS25270 Protein ID WP_047909454.1
Coordinates 75585..75920 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB870_RS25230 70309..71043 - 735 WP_047909448.1 IS6 family transposase -
AB870_RS25235 71160..71570 - 411 Protein_71 DDE-type integrase/transposase/recombinase -
AB870_RS26695 71632..71799 - 168 Protein_72 IS6 family transposase -
AB870_RS25245 72740..73366 - 627 WP_157112551.1 hypothetical protein -
AB870_RS26700 73320..73724 - 405 WP_157112552.1 hypothetical protein -
AB870_RS26180 73755..74489 + 735 WP_084664397.1 IS6 family transposase -
AB870_RS25265 75227..75604 + 378 WP_047909453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AB870_RS25270 75585..75920 + 336 WP_047909454.1 helix-turn-helix domain-containing protein Antitoxin
AB870_RS26880 76040..76369 + 330 Protein_79 hypothetical protein -
AB870_RS25275 76921..77999 + 1079 Protein_80 IS256 family transposase -
AB870_RS25280 78007..79242 - 1236 WP_047909156.1 IS110 family transposase -
AB870_RS25285 79489..79698 + 210 Protein_82 transposase -
AB870_RS25290 79771..80400 - 630 WP_084664403.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..104368 104368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13899.01 Da        Isoelectric Point: 9.4287

>T55070 WP_047909453.1 NZ_CP011809:75227-75604 [Pandoraea faecigallinarum]
MTGNEKPLEWIGGSYRELMALPPDVRRRFGYALSLAQMGDQDDAAKVLKGFGGAGVLEVVEDDVGGTYRVVYTVKFVDAV
FVLHCFQKKSKRGIATPKEDMDIIRARLKVAEARAQELRNAKTNH

Download         Length: 378 bp

>T55070 NZ_CP011809:75227-75604 [Pandoraea faecigallinarum]
ATGACCGGTAATGAAAAGCCACTCGAATGGATTGGGGGAAGCTACAGGGAACTGATGGCGTTACCACCGGACGTGCGCCG
ACGATTCGGCTACGCCCTCTCGCTGGCCCAGATGGGCGATCAGGACGATGCGGCGAAGGTGCTCAAGGGCTTCGGCGGGG
CGGGCGTGCTGGAGGTCGTTGAAGACGATGTCGGCGGCACGTACCGGGTGGTCTACACAGTCAAGTTCGTCGATGCGGTC
TTCGTGCTGCATTGCTTTCAGAAGAAGAGCAAACGCGGGATCGCCACACCGAAAGAGGATATGGACATCATCCGCGCCCG
GCTCAAGGTGGCCGAGGCAAGAGCACAGGAGTTGCGAAATGCAAAAACAAATCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12135.24 Da        Isoelectric Point: 10.1490

>AT55070 WP_047909454.1 NZ_CP011809:75585-75920 [Pandoraea faecigallinarum]
MQKQIIEGVEVQRSSGNVFADLGVPEAQKLKIKTGLVIEIRKAMRALGLTQQAAAERMGISQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPVGHLTLATA

Download         Length: 336 bp

>AT55070 NZ_CP011809:75585-75920 [Pandoraea faecigallinarum]
ATGCAAAAACAAATCATTGAAGGCGTCGAAGTCCAGCGCAGTTCGGGCAACGTCTTCGCCGATCTGGGAGTGCCTGAGGC
GCAGAAACTGAAGATCAAGACGGGCCTGGTGATTGAGATTCGAAAGGCGATGCGTGCGCTTGGGCTGACACAACAAGCGG
CCGCCGAGCGCATGGGTATCTCGCAACCGAAGGTCTCGGGCATGATGCGCGGCGACTTTACCAATTTGTCCGAGCGCAAG
CTCATGGATTGCCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTCCGGCCGGCGGCTGAGCCGGTCGGCCACCTCAC
GCTGGCCACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3X0K4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3X3H3

References