Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 376654..377216 Replicon plasmid pPF72-1
Accession NZ_CP011808
Organism Pandoraea faecigallinarum strain DSM 23572

Toxin (Protein)


Gene name mazE Uniprot ID A0A0H3WZY3
Locus tag AB870_RS24805 Protein ID WP_047909263.1
Coordinates 376654..376974 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID A0A0H3X2T1
Locus tag AB870_RS24810 Protein ID WP_047909264.1
Coordinates 376968..377216 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB870_RS24790 372645..374089 - 1445 Protein_356 autotransporter outer membrane beta-barrel domain-containing protein -
AB870_RS24795 374112..375146 - 1035 WP_047906187.1 IS630 family transposase -
AB870_RS26120 375273..376292 - 1020 WP_084664347.1 IPT/TIG domain-containing protein -
AB870_RS24805 376654..376974 - 321 WP_047909263.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AB870_RS24810 376968..377216 - 249 WP_047909264.1 antitoxin Antitoxin
AB870_RS24815 377511..378566 - 1056 WP_047909265.1 hydrogenase expression/formation protein HypE -
AB870_RS24820 378563..379713 - 1151 Protein_362 hydrogenase formation protein HypD -
AB870_RS26870 379815..379952 - 138 WP_167362761.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..386625 386625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11720.91 Da        Isoelectric Point: 10.0380

>T55068 WP_047909263.1 NZ_CP011808:c376974-376654 [Pandoraea faecigallinarum]
VVARGEIWLVALDPTKGSEIQKTRPCVVVSPAEMHDHLRTVIVAPMTTKGRPAPFRIPITFMRTSGLILLDQLRAVDKVC
LVKKEGAVTDKTLLSTLRTLQEVFAE

Download         Length: 321 bp

>T55068 NZ_CP011808:c376974-376654 [Pandoraea faecigallinarum]
GTGGTAGCGCGCGGGGAGATTTGGCTCGTTGCCCTGGACCCGACAAAGGGTAGCGAAATTCAGAAGACACGGCCGTGTGT
GGTCGTCTCGCCGGCTGAAATGCACGATCATCTGCGCACAGTGATCGTCGCGCCGATGACGACGAAGGGGCGGCCCGCGC
CGTTCCGTATTCCGATTACGTTCATGCGCACGAGCGGGCTGATTTTGCTGGACCAACTTCGCGCCGTGGACAAGGTGTGC
CTGGTAAAGAAAGAGGGCGCCGTTACCGATAAAACGCTATTGAGCACCCTGCGGACGTTGCAGGAAGTCTTTGCAGAGTA
G

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8867.10 Da        Isoelectric Point: 4.2683

>AT55068 WP_047909264.1 NZ_CP011808:c377216-376968 [Pandoraea faecigallinarum]
MRTTIRRMGNSQGVLIPKPILAQLGLEGEVDIAVEDDALVIRKPQKKAREGWAEASQDVAAAGDDALVMGEFSNADDSVL
MW

Download         Length: 249 bp

>AT55068 NZ_CP011808:c377216-376968 [Pandoraea faecigallinarum]
ATGAGAACTACGATTCGAAGGATGGGTAATTCACAGGGGGTACTGATCCCCAAACCGATTCTTGCTCAGCTTGGTCTGGA
GGGGGAAGTGGATATTGCGGTTGAGGACGACGCGCTTGTCATTCGAAAACCGCAAAAGAAGGCGCGTGAGGGCTGGGCTG
AGGCCAGCCAGGATGTGGCCGCTGCTGGCGATGACGCGCTGGTGATGGGCGAGTTTTCCAACGCTGACGATTCGGTGCTG
ATGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3WZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3X2T1

References