Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 294313..294974 Replicon plasmid pPF72-1
Accession NZ_CP011808
Organism Pandoraea faecigallinarum strain DSM 23572

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H3WZS3
Locus tag AB870_RS24395 Protein ID WP_047909213.1
Coordinates 294313..294738 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0H3X2K9
Locus tag AB870_RS24400 Protein ID WP_047909214.1
Coordinates 294735..294974 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB870_RS24380 290501..290803 + 303 Protein_273 IS6 family transposase -
AB870_RS24385 291091..292674 - 1584 WP_047909212.1 hypothetical protein -
AB870_RS24390 292906..293940 + 1035 WP_047906187.1 IS630 family transposase -
AB870_RS24395 294313..294738 - 426 WP_047909213.1 type II toxin-antitoxin system VapC family toxin Toxin
AB870_RS24400 294735..294974 - 240 WP_047909214.1 plasmid stability protein Antitoxin
AB870_RS24405 295204..295896 - 693 WP_047909397.1 IS6 family transposase -
AB870_RS24415 297061..298143 - 1083 WP_047906396.1 IS630 family transposase -
AB870_RS24420 298296..299675 + 1380 WP_157112529.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..386625 386625
- inside IScluster/Tn - - 290009..301669 11660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15278.59 Da        Isoelectric Point: 6.4706

>T55065 WP_047909213.1 NZ_CP011808:c294738-294313 [Pandoraea faecigallinarum]
MILLDTNVLSEPLKAPGDMNVLAWIDAQMIETLYLSTISLAELRFGIAVLPEGKRRDTLHERLEQRVLPLFAGRILSFDA
PASEAYATLRSRARSTGKAIAPADGYIAGIAATHGFAVATRDTSPFDAAGLAVINPWTWRA

Download         Length: 426 bp

>T55065 NZ_CP011808:c294738-294313 [Pandoraea faecigallinarum]
ATGATCCTGCTTGATACTAACGTCCTCTCTGAACCATTGAAAGCGCCTGGCGATATGAACGTCTTGGCGTGGATCGATGC
ACAGATGATTGAAACGCTGTACCTCTCGACAATCAGCCTTGCCGAGCTGCGCTTTGGCATCGCGGTGCTGCCCGAGGGTA
AACGCCGCGACACGCTTCATGAGCGTCTTGAACAGCGTGTCCTGCCGCTATTTGCTGGTCGCATCTTGTCATTCGACGCT
CCCGCCTCGGAAGCCTATGCAACGTTGCGCTCCCGTGCGCGCTCGACCGGAAAAGCCATCGCCCCAGCAGACGGCTACAT
CGCCGGCATAGCGGCGACCCATGGCTTCGCCGTAGCCACACGCGACACATCACCTTTCGACGCTGCCGGCTTGGCCGTCA
TCAATCCTTGGACATGGAGAGCCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8700.79 Da        Isoelectric Point: 5.1601

>AT55065 WP_047909214.1 NZ_CP011808:c294974-294735 [Pandoraea faecigallinarum]
MASVTVRNLTDETHRALRVRAATHGRSTEAEIRAILESAVRPESRIKLGSLLAEIGYEVGGVELEVERDRTPAEPVSFE

Download         Length: 240 bp

>AT55065 NZ_CP011808:c294974-294735 [Pandoraea faecigallinarum]
ATGGCATCTGTCACTGTTCGTAATCTAACTGACGAGACGCACCGTGCCTTGCGCGTGCGCGCTGCTACGCATGGCCGCAG
CACAGAGGCCGAAATTCGGGCAATCCTTGAAAGTGCCGTTCGCCCTGAGAGCCGAATCAAGCTCGGCTCTCTTCTGGCCG
AAATTGGCTACGAAGTAGGCGGCGTCGAGCTTGAGGTCGAGCGTGATAGGACACCGGCCGAGCCGGTGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3WZS3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3X2K9

References