Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 181652..182217 Replicon plasmid pPF72-1
Accession NZ_CP011808
Organism Pandoraea faecigallinarum strain DSM 23572

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H3X0M9
Locus tag AB870_RS23815 Protein ID WP_047909376.1
Coordinates 181652..182023 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0H3X3T9
Locus tag AB870_RS23820 Protein ID WP_047909377.1
Coordinates 182020..182217 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB870_RS23790 178547..178838 + 292 Protein_152 IS6 family transposase -
AB870_RS23795 178879..179622 + 744 WP_047909369.1 IS6 family transposase -
AB870_RS23810 180879..181298 + 420 Protein_155 transposase -
AB870_RS26620 181372..181521 + 150 Protein_156 transposase -
AB870_RS23815 181652..182023 - 372 WP_047909376.1 type II toxin-antitoxin system VapC family toxin Toxin
AB870_RS23820 182020..182217 - 198 WP_047909377.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AB870_RS25945 182373..182549 - 177 WP_167362759.1 integrase core domain-containing protein -
AB870_RS23825 182551..183414 - 864 WP_047909378.1 IS3 family transposase -
AB870_RS23830 183448..184038 - 591 Protein_161 IS30 family transposase -
AB870_RS23835 184065..185627 - 1563 WP_047909433.1 IS66 family transposase -
AB870_RS23840 185659..186009 - 351 WP_047909134.1 IS66 family insertion sequence element accessory protein TnpB -
AB870_RS26625 185985..186212 - 228 WP_157112517.1 hypothetical protein -
AB870_RS25950 186366..187177 + 812 WP_157112514.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..386625 386625
- inside IScluster/Tn - - 180077..199558 19481


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13293.45 Da        Isoelectric Point: 6.4815

>T55063 WP_047909376.1 NZ_CP011808:c182023-181652 [Pandoraea faecigallinarum]
MILVDTSVWIDHLRSGDAALVQLLESGRVLAHPYVIGELALGSLKNRDIVISTLGDLPRVTVATDDEVLRFVGEQALFGL
GIGYVDVHLLAATRLTPGAALWTRDKRLTATAERLSLAAKILH

Download         Length: 372 bp

>T55063 NZ_CP011808:c182023-181652 [Pandoraea faecigallinarum]
ATGATTCTGGTCGACACGTCAGTTTGGATTGATCATTTACGATCAGGTGATGCTGCACTCGTCCAGTTGCTTGAGAGTGG
ACGAGTGTTGGCGCATCCGTATGTCATCGGAGAGCTTGCGCTGGGTAGCCTGAAGAATCGCGACATCGTGATTTCAACGC
TGGGCGATCTACCTCGCGTCACAGTTGCCACCGATGACGAGGTGTTGCGGTTCGTCGGTGAGCAAGCGCTCTTCGGTTTG
GGGATCGGCTATGTTGATGTCCATCTACTTGCCGCAACTCGTCTGACTCCGGGAGCCGCCTTGTGGACTAGAGACAAGCG
TCTTACTGCGACGGCCGAACGGCTTTCGTTGGCCGCGAAAATCTTGCACTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7101.10 Da        Isoelectric Point: 6.2999

>AT55063 WP_047909377.1 NZ_CP011808:c182217-182020 [Pandoraea faecigallinarum]
VRTTLALDDDLLAKAQAFTGLQEKSALIREALKALIERESARRLARLGGTEADLGDIPRRQTEPA

Download         Length: 198 bp

>AT55063 NZ_CP011808:c182217-182020 [Pandoraea faecigallinarum]
GTGCGAACGACTTTGGCTCTTGACGATGATCTTTTGGCAAAGGCTCAAGCCTTCACCGGCTTGCAGGAAAAATCAGCGCT
GATCCGTGAGGCACTCAAGGCGCTGATCGAGCGCGAAAGCGCCCGCCGCTTGGCTCGTTTGGGTGGGACCGAGGCTGACC
TTGGTGACATTCCTCGACGCCAAACGGAGCCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3X0M9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3X3T9

References