Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 66511..67110 Replicon plasmid pPF72-1
Accession NZ_CP011808
Organism Pandoraea faecigallinarum strain DSM 23572

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AB870_RS23345 Protein ID WP_157112541.1
Coordinates 66511..66810 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AB870_RS23350 Protein ID WP_047909313.1
Coordinates 66814..67110 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB870_RS23310 61618..62061 - 444 WP_047909416.1 Hsp20/alpha crystallin family protein -
AB870_RS23315 62307..62690 + 384 WP_047909309.1 hypothetical protein -
AB870_RS23320 63051..63302 - 252 Protein_59 transposase -
AB870_RS23325 63364..63624 + 261 Protein_60 DDE-type integrase/transposase/recombinase -
AB870_RS23330 63790..64743 - 954 WP_157112501.1 hypothetical protein -
AB870_RS23335 65605..66222 + 618 WP_157112502.1 IS6 family transposase -
AB870_RS25855 66303..66425 - 123 Protein_63 IS3 family transposase -
AB870_RS23345 66511..66810 + 300 WP_157112541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AB870_RS23350 66814..67110 + 297 WP_047909313.1 putative addiction module antidote protein Antitoxin
AB870_RS23355 67154..67635 + 482 Protein_66 IS6 family transposase -
AB870_RS23360 67719..68030 + 312 Protein_67 transposase -
AB870_RS23370 68095..69275 + 1181 Protein_68 IS3 family transposase -
AB870_RS23375 69611..70316 + 706 Protein_69 plasmid stabilization protein -
AB870_RS23380 70449..71468 + 1020 WP_047905322.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..386625 386625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11101.84 Da        Isoelectric Point: 8.9948

>T55062 WP_157112541.1 NZ_CP011808:66511-66810 [Pandoraea faecigallinarum]
MILIRTTDVFDAWFESLKDRMAKRRIQARIDRLAMGNPGDTNSAGAPITELRVDHGPGYRVYYVQRGAVMVILLCGGDKS
TQASDIKAAHRMLPHLDME

Download         Length: 300 bp

>T55062 NZ_CP011808:66511-66810 [Pandoraea faecigallinarum]
ATGATCCTAATCCGTACCACCGACGTATTCGACGCATGGTTCGAGAGCCTCAAGGACCGCATGGCAAAGCGCCGCATCCA
AGCTCGCATTGATCGTTTGGCGATGGGCAATCCCGGCGATACCAACTCTGCCGGAGCCCCGATTACCGAATTGCGGGTTG
ATCACGGTCCCGGCTACCGCGTCTACTACGTGCAGCGCGGCGCTGTGATGGTCATCCTGCTGTGCGGTGGCGACAAATCA
ACGCAGGCATCGGACATCAAGGCCGCGCATCGGATGCTGCCCCACCTTGACATGGAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10638.09 Da        Isoelectric Point: 5.1131

>AT55062 WP_047909313.1 NZ_CP011808:66814-67110 [Pandoraea faecigallinarum]
MEKIKTRPWDSAEYLKTEEDVTEYFEACLLEGGDDPAFIAQALGVIARARGMTQVARDAGLTREGLYKALSSDGNPSFGT
ILRVIKALGLQLHATAHA

Download         Length: 297 bp

>AT55062 NZ_CP011808:66814-67110 [Pandoraea faecigallinarum]
ATGGAGAAAATCAAAACCCGGCCGTGGGATTCGGCCGAATATCTGAAGACCGAAGAAGATGTCACCGAATATTTTGAGGC
ATGTCTTCTAGAAGGCGGTGACGATCCCGCATTCATTGCTCAAGCACTTGGCGTGATTGCCCGCGCACGCGGTATGACGC
AAGTTGCCCGCGATGCTGGTTTGACACGGGAAGGCCTGTACAAGGCGTTGTCGAGCGATGGCAACCCGAGCTTTGGAACC
ATTTTAAGAGTCATCAAAGCGCTTGGGTTGCAATTGCACGCAACGGCACATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References