Detailed information of TA system TA055056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 4096870..4097299
• Replicon: chromosome
• Accession: NZ_CP011801
• Organism: Nitrospira moscoviensis strain NSP M-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: NITMOv2_RS20035
• Protein ID: WP_202967387.1
• Coordinates: 4096870..4097085 (+)
• Length: 72 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: NITMOv2_RS20040
• Protein ID: WP_053381543.1
• Coordinates: 4097087..4097299 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NITMOv2_RS20005	4092221..4093537	-	1317	WP_053381539.1	GAF domain-containing sensor histidine kinase	-
NITMOv2_RS20010	4093754..4094218	-	465	WP_053381540.1	response regulator	-
NITMOv2_RS20015	4094257..4094694	-	438	WP_053381541.1	response regulator	-
NITMOv2_RS20020	4094906..4096261	+	1356	WP_053382175.1	sigma-54 dependent transcriptional regulator	-
NITMOv2_RS20035	4096870..4097085	+	216	WP_202967387.1	type II toxin-antitoxin system HicA family toxin	Toxin
NITMOv2_RS20040	4097087..4097299	+	213	WP_053381543.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NITMOv2_RS23065	4097498..4097740	+	243	WP_083448242.1	helix-turn-helix domain-containing protein	-
NITMOv2_RS20045	4097957..4098205	+	249	WP_202967275.1	type II toxin-antitoxin system HigB family toxin	-
NITMOv2_RS20050	4098219..4099418	+	1200	WP_053381545.1	ImmA/IrrE family metallo-endopeptidase	-
NITMOv2_RS20055	4099434..4100474	+	1041	WP_053381546.1	beta family protein	-
NITMOv2_RS23070	4100428..4101429	-	1002	WP_202967276.1	TIGR02391 family protein	-
NITMOv2_RS23075	4101684..4102043	-	360	WP_187299454.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4090399..4110228	19829

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (12-66)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-64)

Sequences

Toxin

Protein

• Length: 72 a.a.
• Molecular weight: 7987.25 Da
• Isoelectric Point: 11.2257

>T55056 WP_202967387.1 NZ_CP011801:4096870-4097085 [Nitrospira moscoviensis]
MRYPHAVKVGDILDRLRQDGWFLVATKGSHRQFKHQTKPGRVTVAGKLSDDLPPGTLNSIFKQAGWKKGMN

Nucleotide

• Length: 216 bp

>T55056 NZ_CP011801:4096870-4097085 [Nitrospira moscoviensis]
CTGCGCTATCCTCACGCCGTGAAAGTTGGGGATATCCTCGACAGATTGCGACAAGACGGCTGGTTCCTCGTTGCGACGAA
GGGCAGTCACCGACAGTTCAAACACCAAACTAAACCAGGTCGCGTGACCGTTGCCGGCAAGCTCAGCGACGACTTGCCTC
CTGGAACGTTGAATAGTATTTTTAAGCAAGCTGGCTGGAAGAAGGGGATGAACTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7453.44 Da
• Isoelectric Point: 4.0830

>AT55056 WP_053381543.1 NZ_CP011801:4097087-4097299 [Nitrospira moscoviensis]
VRYAVVIEKAPSNYAAYVPDLPGCVATGSTVAETETLIREAIEFHLEGLKADGLPIPPPNSQVEYVDVPA

Nucleotide

• Length: 213 bp

>AT55056 NZ_CP011801:4097087-4097299 [Nitrospira moscoviensis]
GTGCGTTATGCGGTCGTGATTGAGAAAGCTCCGTCGAATTATGCCGCCTATGTTCCGGACCTGCCTGGCTGCGTTGCGAC
GGGTTCCACCGTGGCGGAAACTGAAACCCTGATTCGAGAAGCCATCGAATTTCATTTGGAGGGTCTGAAAGCAGACGGCC
TCCCAATCCCCCCGCCGAACAGCCAAGTCGAATACGTCGATGTCCCAGCCTGA