Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 4096870..4097299 Replicon chromosome
Accession NZ_CP011801
Organism Nitrospira moscoviensis strain NSP M-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NITMOv2_RS20035 Protein ID WP_202967387.1
Coordinates 4096870..4097085 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NITMOv2_RS20040 Protein ID WP_053381543.1
Coordinates 4097087..4097299 (+) Length 71 a.a.

Genomic Context

NITMOv2_RS20020NITMOv2_RS20035NITMOv2_RS20040NITMOv2_RS23065NITMOv2_RS20045NITMOv2_RS20050NITMOv2_RS20055NITMOv2_RS20005NITMOv2_RS20010NITMOv2_RS20015NITMOv2_RS23070NITMOv2_RS23075
Location: 4094906..4096261 (1356 bp)
Type: Others
Protein ID: WP_053382175.1
Location: 4096870..4097085 (216 bp)
Type: Toxin
Protein ID: WP_202967387.1
Location: 4097087..4097299 (213 bp)
Type: Antitoxin
Protein ID: WP_053381543.1
Location: 4097498..4097740 (243 bp)
Type: Others
Protein ID: WP_083448242.1
Location: 4097957..4098205 (249 bp)
Type: Others
Protein ID: WP_202967275.1
Location: 4098219..4099418 (1200 bp)
Type: Others
Protein ID: WP_053381545.1
Location: 4099434..4100474 (1041 bp)
Type: Others
Protein ID: WP_053381546.1
Location: 4092221..4093537 (1317 bp)
Type: Others
Protein ID: WP_053381539.1
Location: 4093754..4094218 (465 bp)
Type: Others
Protein ID: WP_053381540.1
Location: 4094257..4094694 (438 bp)
Type: Others
Protein ID: WP_053381541.1
Location: 4100428..4101429 (1002 bp)
Type: Others
Protein ID: WP_202967276.1
Location: 4101684..4102043 (360 bp)
Type: Others
Protein ID: WP_187299454.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NITMOv2_RS200054092221..4093537-1317WP_053381539.1GAF domain-containing sensor histidine kinase-
NITMOv2_RS200104093754..4094218-465WP_053381540.1response regulator-
NITMOv2_RS200154094257..4094694-438WP_053381541.1response regulator-
NITMOv2_RS200204094906..4096261+1356WP_053382175.1sigma-54 dependent transcriptional regulator-
NITMOv2_RS200354096870..4097085+216WP_202967387.1type II toxin-antitoxin system HicA family toxinToxin
NITMOv2_RS200404097087..4097299+213WP_053381543.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
NITMOv2_RS230654097498..4097740+243WP_083448242.1helix-turn-helix domain-containing protein-
NITMOv2_RS200454097957..4098205+249WP_202967275.1type II toxin-antitoxin system HigB family toxin-
NITMOv2_RS200504098219..4099418+1200WP_053381545.1ImmA/IrrE family metallo-endopeptidase-
NITMOv2_RS200554099434..4100474+1041WP_053381546.1beta family protein-
NITMOv2_RS230704100428..4101429-1002WP_202967276.1TIGR02391 family protein-
NITMOv2_RS230754101684..4102043-360WP_187299454.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--4090399..411022819829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(12-66)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 7987.25 Da        Isoelectric Point: 11.2257

>T55056 WP_202967387.1 NZ_CP011801:4096870-4097085 [Nitrospira moscoviensis]
MRYPHAVKVGDILDRLRQDGWFLVATKGSHRQFKHQTKPGRVTVAGKLSDDLPPGTLNSIFKQAGWKKGMN

Download         Length: 216 bp

>T55056 NZ_CP011801:4096870-4097085 [Nitrospira moscoviensis]
CTGCGCTATCCTCACGCCGTGAAAGTTGGGGATATCCTCGACAGATTGCGACAAGACGGCTGGTTCCTCGTTGCGACGAA
GGGCAGTCACCGACAGTTCAAACACCAAACTAAACCAGGTCGCGTGACCGTTGCCGGCAAGCTCAGCGACGACTTGCCTC
CTGGAACGTTGAATAGTATTTTTAAGCAAGCTGGCTGGAAGAAGGGGATGAACTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7453.44 Da        Isoelectric Point: 4.0830

>AT55056 WP_053381543.1 NZ_CP011801:4097087-4097299 [Nitrospira moscoviensis]
VRYAVVIEKAPSNYAAYVPDLPGCVATGSTVAETETLIREAIEFHLEGLKADGLPIPPPNSQVEYVDVPA

Download         Length: 213 bp

>AT55056 NZ_CP011801:4097087-4097299 [Nitrospira moscoviensis]
GTGCGTTATGCGGTCGTGATTGAGAAAGCTCCGTCGAATTATGCCGCCTATGTTCCGGACCTGCCTGGCTGCGTTGCGAC
GGGTTCCACCGTGGCGGAAACTGAAACCCTGATTCGAGAAGCCATCGAATTTCATTTGGAGGGTCTGAAAGCAGACGGCC
TCCCAATCCCCCCGCCGAACAGCCAAGTCGAATACGTCGATGTCCCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References