Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1000606..1001237 Replicon chromosome
Accession NZ_CP011801
Organism Nitrospira moscoviensis strain NSP M-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NITMOv2_RS04895 Protein ID WP_053378824.1
Coordinates 1000606..1001004 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NITMOv2_RS04900 Protein ID WP_053378825.1
Coordinates 1001001..1001237 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NITMOv2_RS04880 996244..998574 + 2331 WP_053378821.1 6-phosphofructokinase -
NITMOv2_RS04885 998581..1000020 - 1440 WP_053378822.1 hypothetical protein -
NITMOv2_RS04890 1000068..1000565 - 498 WP_053378823.1 sigma-70 family RNA polymerase sigma factor -
NITMOv2_RS04895 1000606..1001004 - 399 WP_053378824.1 type II toxin-antitoxin system VapC family toxin Toxin
NITMOv2_RS04900 1001001..1001237 - 237 WP_053378825.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NITMOv2_RS04905 1001364..1001912 - 549 WP_053378826.1 hypothetical protein -
NITMOv2_RS04910 1001909..1002637 - 729 WP_053378827.1 DUF3592 domain-containing protein -
NITMOv2_RS04915 1002642..1003361 - 720 WP_053378828.1 DUF3592 domain-containing protein -
NITMOv2_RS04920 1003772..1004935 - 1164 WP_145976172.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14724.22 Da        Isoelectric Point: 8.0278

>T55055 WP_053378824.1 NZ_CP011801:c1001004-1000606 [Nitrospira moscoviensis]
MKLMLDTNICIYLIKKHPVSVLDRFRSFQVGTIGISIITLAELLYGVAKSRDPARNREALSEFTAPLEVAPFDTDAAAEY
GRVRTVLEKQGRLIGAMDLLIAAHAVSLDVTLITNNIAEFKRVPRLNVENWL

Download         Length: 399 bp

>T55055 NZ_CP011801:c1001004-1000606 [Nitrospira moscoviensis]
ATGAAGCTCATGCTCGATACCAACATCTGCATTTACCTCATTAAAAAACACCCGGTCTCCGTTCTCGATCGCTTTCGCTC
GTTTCAGGTCGGAACAATCGGCATCTCCATCATCACGCTGGCGGAACTCTTGTACGGCGTGGCAAAGAGCCGTGATCCTG
CACGCAACCGAGAAGCGCTCAGCGAGTTTACCGCGCCTCTTGAGGTCGCGCCGTTCGATACCGACGCGGCTGCCGAATAC
GGCCGTGTCAGAACCGTCTTGGAAAAACAGGGTCGCCTCATCGGAGCCATGGATCTCCTGATCGCAGCTCATGCAGTAAG
CCTGGATGTGACTCTCATCACCAACAACATCGCCGAGTTTAAGCGCGTGCCACGATTGAACGTGGAGAACTGGTTATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9140.68 Da        Isoelectric Point: 12.2984

>AT55055 WP_053378825.1 NZ_CP011801:c1001237-1001001 [Nitrospira moscoviensis]
MKTAKIFRSGNSQAVRIPREFHLEGTEVEIRRQGDVLVLRPKKPSWNVMMSSFSKFTSDFMKRGRKQPRVQKRGRAFS

Download         Length: 237 bp

>AT55055 NZ_CP011801:c1001237-1001001 [Nitrospira moscoviensis]
ATGAAGACTGCGAAAATTTTCCGCAGCGGCAACAGTCAGGCGGTGCGCATTCCGCGAGAGTTTCATCTTGAGGGCACCGA
AGTGGAGATACGGCGGCAAGGCGATGTGCTCGTCTTACGCCCCAAGAAACCGTCTTGGAACGTGATGATGAGCAGCTTCT
CGAAATTCACGAGCGACTTCATGAAAAGGGGGCGAAAACAGCCTCGCGTCCAGAAGCGCGGACGCGCCTTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References