Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4478665..4479322 Replicon chromosome
Accession NZ_CP011798
Organism Enterobacter ludwigii strain UW5

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag ABT55_RS21035 Protein ID WP_014171514.1
Coordinates 4478665..4479075 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ABT55_RS21040 Protein ID WP_003863437.1
Coordinates 4479056..4479322 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABT55_RS21015 4474663..4476396 - 1734 WP_020883732.1 single-stranded-DNA-specific exonuclease RecJ -
ABT55_RS21020 4476402..4477115 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ABT55_RS21025 4477139..4478035 - 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
ABT55_RS21030 4478137..4478658 + 522 WP_014171513.1 flavodoxin FldB -
ABT55_RS21035 4478665..4479075 - 411 WP_014171514.1 protein YgfX Toxin
ABT55_RS21040 4479056..4479322 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ABT55_RS21045 4479617..4480597 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
ABT55_RS21050 4480708..4481367 - 660 WP_014171517.1 hemolysin III family protein -
ABT55_RS21055 4481634..4482365 + 732 WP_020883729.1 MurR/RpiR family transcriptional regulator -
ABT55_RS21060 4482482..4483915 + 1434 WP_032678925.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T55048 WP_014171514.1 NZ_CP011798:c4479075-4478665 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T55048 NZ_CP011798:c4479075-4478665 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCTGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT55048 WP_003863437.1 NZ_CP011798:c4479322-4479056 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT55048 NZ_CP011798:c4479322-4479056 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References