Detailed information of TA system TA055047

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4202547..4203294
• Replicon: chromosome
• Accession: NZ_CP011798
• Organism: Enterobacter ludwigii strain UW5

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: ABT55_RS19725
• Protein ID: WP_047955989.1
• Coordinates: 4202899..4203294 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A7U4N5G9
• Locus tag: ABT55_RS19720
• Protein ID: WP_021555652.1
• Coordinates: 4202547..4202867 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABT55_RS19685	4197735..4198370	-	636	WP_021555644.1	inovirus Gp2 family protein	-
ABT55_RS19690	4198951..4199385	+	435	WP_047955983.1	hypothetical protein	-
ABT55_RS19695	4199405..4200208	+	804	WP_047955984.1	hypothetical protein	-
ABT55_RS19700	4200425..4200901	+	477	WP_080346978.1	hypothetical protein	-
ABT55_RS19705	4200973..4201794	+	822	WP_047955986.1	DUF945 domain-containing protein	-
ABT55_RS19710	4201827..4202300	+	474	WP_047955987.1	DNA repair protein RadC	-
ABT55_RS19715	4202308..4202529	+	222	WP_047955988.1	DUF987 family protein	-
ABT55_RS19720	4202547..4202867	+	321	WP_021555652.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ABT55_RS19725	4202899..4203294	+	396	WP_047955989.1	TA system toxin CbtA family protein	Toxin
ABT55_RS19730	4203571..4204755	+	1185	WP_047955990.1	tyrosine-type recombinase/integrase	-
ABT55_RS19735	4204936..4206414	+	1479	WP_047955991.1	hypothetical protein	-
ABT55_RS19740	4206417..4207319	+	903	WP_047955992.1	DNA adenine methylase	-
ABT55_RS19745	4207763..4208083	-	321	WP_047955993.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4187754..4210677	22923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-108)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14733.93 Da
• Isoelectric Point: 6.6428

>T55047 WP_047955989.1 NZ_CP011798:4202899-4203294 [Enterobacter ludwigii]
MHILSVPTTVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQDQTPFLSATDILRARRATGIMSTSVVSISFPMSLPFTNPNRVKKLLGT

Nucleotide

• Length: 396 bp

>T55047 NZ_CP011798:4202899-4203294 [Enterobacter ludwigii]
ATGCACATTTTATCTGTACCGACCACGGTGCCAGTTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGAGCACCATTACGGACTGACGCTTAACGACACGCCATTCCACGACGACGCTGCTATCGAAGAACATATCG
AGGCGGGAATAACACTTGCTGATGCGGTGAATTTCCTGGTCGAAAAATACGAACTGGTTCGTATCGACCGGAAGGGATTT
TCATGGCAGGATCAAACGCCATTCCTCAGCGCTACCGATATTCTCAGAGCAAGGCGAGCTACGGGGATAATGAGCACTTC
AGTAGTGTCAATCTCCTTCCCTATGTCTCTTCCTTTTACTAACCCAAATAGGGTGAAAAAACTTTTAGGCACCTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11973.67 Da
• Isoelectric Point: 6.4764

>AT55047 WP_021555652.1 NZ_CP011798:4202547-4202867 [Enterobacter ludwigii]
MKNSWGLKRDMTPCFGARLVQEGCRLHFLADRADISGAFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQTSSQ

Nucleotide

• Length: 321 bp

>AT55047 NZ_CP011798:4202547-4202867 [Enterobacter ludwigii]
ATGAAAAATTCATGGGGACTGAAGCGCGACATGACGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGATATTAGCGGTGCGTTTAATGAGGAGGAGGCGCTACGTCTCGATCAAGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTAAATCCACGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGCGAGGCGGATACTCTCGGCTCTCATGGCTACGTTTACATCGTTATTTATCCTCAGACATCGAGCCAGTA
A

Structures

Antitoxin

• AlphaFold DB: A0A7U4N5G9