Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1585794..1586474 Replicon chromosome
Accession NZ_CP011798
Organism Enterobacter ludwigii strain UW5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7U4N130
Locus tag ABT55_RS07495 Protein ID WP_047955154.1
Coordinates 1586154..1586474 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U4N148
Locus tag ABT55_RS07490 Protein ID WP_047955153.1
Coordinates 1585794..1586117 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABT55_RS07455 1580996..1581871 + 876 WP_047955147.1 GTPase family protein -
ABT55_RS07460 1582084..1582785 + 702 WP_024484792.1 WYL domain-containing protein -
ABT55_RS07465 1582791..1583357 + 567 WP_047955148.1 hypothetical protein -
ABT55_RS07470 1583396..1583848 + 453 WP_047955149.1 hypothetical protein -
ABT55_RS07475 1583845..1584297 + 453 WP_047955150.1 hypothetical protein -
ABT55_RS07480 1584419..1585240 + 822 WP_047955151.1 DUF945 domain-containing protein -
ABT55_RS07485 1585310..1585780 + 471 WP_047955152.1 DNA repair protein RadC -
ABT55_RS07490 1585794..1586117 + 324 WP_047955153.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ABT55_RS07495 1586154..1586474 + 321 WP_047955154.1 TA system toxin CbtA family protein Toxin
ABT55_RS07500 1586588..1587421 + 834 WP_047955155.1 DUF4942 domain-containing protein -
ABT55_RS07505 1587872..1588888 + 1017 WP_047955156.1 iron ABC transporter substrate-binding protein -
ABT55_RS07510 1588913..1590487 + 1575 WP_014168956.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1565745..1587729 21984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12039.69 Da        Isoelectric Point: 5.4503

>T55038 WP_047955154.1 NZ_CP011798:1586154-1586474 [Enterobacter ludwigii]
MHISSVPATVPVASRLSPVQVWQQLLTYLLDHHYGLTLNDTPFHDDMTIQEHIEAGITLADAVNFLVECYELVRTDRKGF
SWQEQTPFLTATDILRARRATGLMNT

Download         Length: 321 bp

>T55038 NZ_CP011798:1586154-1586474 [Enterobacter ludwigii]
ATGCACATTTCATCTGTACCGGCCACGGTGCCGGTTGCGTCGCGCTTGTCACCCGTGCAAGTCTGGCAGCAACTTTTAAC
GTATCTGCTGGACCACCATTACGGCCTCACACTCAACGACACACCATTCCATGATGACATGACCATCCAGGAACATATCG
AGGCAGGGATCACGCTTGCCGATGCAGTGAATTTCTTGGTGGAGTGCTATGAACTGGTGCGCACTGATCGTAAGGGTTTC
AGTTGGCAGGAGCAGACGCCATTCCTGACCGCCACCGATATTCTCAGAGCAAGGCGTGCTACCGGGCTGATGAATACGTA
A

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11965.67 Da        Isoelectric Point: 7.0473

>AT55038 WP_047955153.1 NZ_CP011798:1585794-1586117 [Enterobacter ludwigii]
MPLTPPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFNPKQLQKLDQAFPLFIDLLQAMLHSGELNPHHQHQVT
IQLAGLTCIADTRGSCGYVYISIYPTQ

Download         Length: 324 bp

>AT55038 NZ_CP011798:1585794-1586117 [Enterobacter ludwigii]
ATGCCATTAACACCACCTCATGAATGGGGGTTACAAAGCGATATCACCCCGCGATTTGGCGCAAGATTGGTTCAGGAAGG
TAACCGGCTGCATTACCTGGCTGACAGGGCTGGGTTGACGGGGAGCTTTAACCCTAAGCAATTACAGAAACTGGATCAGG
CTTTCCCGTTGTTTATAGATCTGCTGCAAGCAATGCTGCATTCCGGTGAGCTAAATCCACACCATCAACATCAGGTGACC
ATTCAGCTTGCGGGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCAACCCA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4N130

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4N148

References