Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1313714..1314252 Replicon chromosome
Accession NZ_CP011786
Organism Bifidobacterium actinocoloniiforme DSM 22766

Toxin (Protein)


Gene name yoeB Uniprot ID A0A086Z2H1
Locus tag AB656_RS05435 Protein ID WP_033503960.1
Coordinates 1313995..1314252 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A086Z2H0
Locus tag AB656_RS05430 Protein ID WP_033503961.1
Coordinates 1313714..1313998 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB656_RS05420 1308757..1311357 + 2601 WP_051905400.1 YhgE/Pip domain-containing protein -
AB656_RS05425 1311458..1313620 + 2163 WP_033503962.1 YhgE/Pip domain-containing protein -
AB656_RS05430 1313714..1313998 + 285 WP_033503961.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AB656_RS05435 1313995..1314252 + 258 WP_033503960.1 Txe/YoeB family addiction module toxin Toxin
AB656_RS08025 1314465..1314611 + 147 WP_193786715.1 hypothetical protein -
AB656_RS05445 1314882..1315202 - 321 WP_033503959.1 hypothetical protein -
AB656_RS07860 1315294..1315398 + 105 WP_144418947.1 MerR family transcriptional regulator -
AB656_RS05450 1315453..1315650 + 198 WP_033503958.1 hypothetical protein -
AB656_RS05455 1315780..1316166 + 387 WP_033503969.1 VOC family protein -
AB656_RS05460 1316483..1317373 + 891 WP_033503956.1 3-hydroxyacyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10050.44 Da        Isoelectric Point: 10.1347

>T55032 WP_033503960.1 NZ_CP011786:1313995-1314252 [Bifidobacterium actinocoloniiforme DSM 22766]
MILGWTEDAWEDYRYWQSQDRKTLKRINTLILDTLRHPDSGIGKPEPLKWGLQGAWSRRIDSANRLIYTFTATKLTILSA
RSHYQ

Download         Length: 258 bp

>T55032 NZ_CP011786:1313995-1314252 [Bifidobacterium actinocoloniiforme DSM 22766]
ATGATTCTGGGCTGGACCGAAGACGCTTGGGAGGACTACCGCTACTGGCAGTCCCAGGACCGTAAAACCCTCAAGCGCAT
CAACACCCTGATTCTCGACACCCTCCGCCATCCCGACTCCGGCATCGGCAAGCCCGAGCCGCTCAAGTGGGGTCTCCAAG
GCGCCTGGTCGCGCCGCATAGACTCCGCCAACCGCCTCATATACACCTTCACCGCCACCAAACTGACCATCCTCTCCGCC
CGCAGCCACTACCAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10594.79 Da        Isoelectric Point: 4.3712

>AT55032 WP_033503961.1 NZ_CP011786:1313714-1313998 [Bifidobacterium actinocoloniiforme DSM 22766]
MQAVAYSNFRKSLKAYMHKVNEDADMLLVTNTDPEDNVVVMSADDYDSLMETLRIYQNPYLRDKITRGLAAVAQGQASEH
SLVDDDEPERRAAA

Download         Length: 285 bp

>AT55032 NZ_CP011786:1313714-1313998 [Bifidobacterium actinocoloniiforme DSM 22766]
ATGCAGGCCGTAGCGTACAGCAACTTCCGCAAGAGCCTTAAGGCGTACATGCATAAGGTCAACGAGGACGCGGATATGCT
CCTGGTGACCAACACCGACCCAGAAGACAACGTGGTCGTGATGAGCGCCGATGATTACGACTCCCTCATGGAGACCCTAC
GCATCTACCAAAACCCGTATCTGCGCGATAAAATCACCCGCGGTCTGGCAGCGGTAGCTCAGGGCCAGGCCAGCGAACAC
AGCCTGGTCGACGACGACGAGCCGGAGCGCCGGGCGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086Z2H1

Antitoxin

Source ID Structure
AlphaFold DB A0A086Z2H0

References