Detailed information of TA system TA055031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 376233..376792
• Replicon: chromosome
• Accession: NZ_CP011776
• Organism: Vibrio vulnificus strain FORC_016

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC16_RS16425
• Protein ID: WP_060533350.1
• Coordinates: 376514..376792 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q0L0M2
• Locus tag: FORC16_RS16420
• Protein ID: WP_011082348.1
• Coordinates: 376233..376517 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC16_RS16390	371775..372203	-	429	WP_060534770.1	hypothetical protein	-
FORC16_RS16395	372298..372708	-	411	WP_060533342.1	hypothetical protein	-
FORC16_RS16400	373161..373772	-	612	WP_155736749.1	hypothetical protein	-
FORC16_RS16405	373844..374485	-	642	WP_060533346.1	hypothetical protein	-
FORC16_RS23890	374610..374702	-	93	WP_080537027.1	DUF3265 domain-containing protein	-
FORC16_RS16410	374699..374950	-	252	WP_060533348.1	hypothetical protein	-
FORC16_RS16415	375190..375999	-	810	WP_060534772.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
FORC16_RS16420	376233..376517	+	285	WP_011082348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FORC16_RS16425	376514..376792	+	279	WP_060533350.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC16_RS23895	376821..376913	-	93	WP_196374755.1	DUF3265 domain-containing protein	-
FORC16_RS16430	377233..377487	-	255	Protein_304	hypothetical protein	-
FORC16_RS16435	377497..377997	-	501	WP_038939959.1	hypothetical protein	-
FORC16_RS16440	378375..379343	+	969	WP_081036337.1	IS30 family transposase	-
FORC16_RS16445	379375..379809	-	435	WP_038939960.1	hypothetical protein	-
FORC16_RS16450	379788..380222	-	435	WP_060533352.1	hypothetical protein	-
FORC16_RS23900	380372..380464	-	93	WP_079856523.1	DUF3265 domain-containing protein	-
FORC16_RS16455	380509..381102	-	594	WP_060533354.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	371775..382672	10897
	-	flank	IS/Tn	-	-	378375..379343	968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-45)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10975.69 Da
• Isoelectric Point: 4.3430

>T55031 WP_060533350.1 NZ_CP011776:376514-376792 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDVPEKTDNLIEAKVENLLEQPLMGVQRDSIRGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T55031 NZ_CP011776:376514-376792 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGTGCC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCGCGGTCGATTACTCATTATTCCAGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTTCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.43 Da
• Isoelectric Point: 9.2167

>AT55031 WP_011082348.1 NZ_CP011776:376233-376517 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT55031 NZ_CP011776:376233-376517 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCAGAGAGTCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGTTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q0L0M2