Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1671850..1672388 Replicon chromosome
Accession NZ_CP011775
Organism Vibrio vulnificus strain FORC_016

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC16_RS07665 Protein ID WP_001247271.1
Coordinates 1672089..1672388 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag FORC16_RS07660 Protein ID WP_011080384.1
Coordinates 1671850..1672092 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC16_RS07625 1667555..1668223 - 669 WP_060531578.1 hypothetical protein -
FORC16_RS23070 1668263..1668355 - 93 WP_193288685.1 DUF3265 domain-containing protein -
FORC16_RS07630 1668401..1668925 - 525 WP_060531596.1 AAA family ATPase -
FORC16_RS23075 1668971..1669063 - 93 WP_081036221.1 DUF3265 domain-containing protein -
FORC16_RS07635 1669085..1669375 - 291 WP_060531595.1 hypothetical protein -
FORC16_RS07645 1669528..1670678 + 1151 WP_155521457.1 IS3 family transposase -
FORC16_RS07650 1670675..1671067 - 393 WP_060531588.1 hypothetical protein -
FORC16_RS23080 1671076..1671186 - 111 Protein_1503 DUF3265 domain-containing protein -
FORC16_RS07655 1671204..1671623 - 420 WP_060531586.1 RDD family protein -
FORC16_RS07660 1671850..1672092 + 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC16_RS07665 1672089..1672388 + 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC16_RS23085 1672322..1672507 - 186 WP_081036220.1 DUF3265 domain-containing protein -
FORC16_RS23090 1672869..1672958 - 90 WP_196763485.1 DUF3265 domain-containing protein -
FORC16_RS07670 1672986..1673501 - 516 WP_060531584.1 GNAT family N-acetyltransferase -
FORC16_RS23095 1673519..1673641 - 123 WP_081036308.1 DUF3265 domain-containing protein -
FORC16_RS23100 1673986..1674114 - 129 WP_081036307.1 DUF3265 domain-containing protein -
FORC16_RS07675 1674124..1674546 - 423 WP_060531582.1 VOC family protein -
FORC16_RS23105 1674483..1674704 - 222 WP_081036219.1 DUF3265 domain-containing protein -
FORC16_RS07680 1674701..1675174 - 474 WP_064490488.1 hypothetical protein -
FORC16_RS07685 1675316..1675678 - 363 WP_011150416.1 hypothetical protein -
FORC16_RS23110 1675623..1675817 - 195 WP_081036218.1 DUF3265 domain-containing protein -
FORC16_RS07690 1676284..1676952 - 669 WP_060531578.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1610914..1786420 175506
- inside Integron - - 1662584..1786420 123836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T55029 WP_001247271.1 NZ_CP011775:1672089-1672388 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T55029 NZ_CP011775:1672089-1672388 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT55029 WP_011080384.1 NZ_CP011775:1671850-1672092 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT55029 NZ_CP011775:1671850-1672092 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
ATCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References