Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5166750..5167405 Replicon chromosome
Accession NZ_CP011773
Organism Mycobacterium sp. EPa45

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A0G3IVI5
Locus tag AB431_RS24380 Protein ID WP_047332101.1
Coordinates 5166750..5167196 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID A0A0G3IT93
Locus tag AB431_RS24385 Protein ID WP_047332102.1
Coordinates 5167199..5167405 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB431_RS24355 5163462..5164322 + 861 WP_144418518.1 hypothetical protein -
AB431_RS24360 5164319..5165206 - 888 WP_047332098.1 amidohydrolase family protein -
AB431_RS24365 5165316..5165975 + 660 WP_047332099.1 response regulator transcription factor -
AB431_RS24370 5165977..5166204 - 228 WP_052960387.1 hypothetical protein -
AB431_RS24375 5166345..5166728 + 384 WP_047332100.1 hypothetical protein -
AB431_RS24380 5166750..5167196 - 447 WP_047332101.1 SRPBCC family protein Toxin
AB431_RS24385 5167199..5167405 - 207 WP_047332102.1 antitoxin Antitoxin
AB431_RS24390 5167409..5169808 - 2400 WP_047332103.1 HAD-IC family P-type ATPase -
AB431_RS24395 5169837..5171423 - 1587 WP_047332104.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(9-55)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15993.70 Da        Isoelectric Point: 10.1634

>T55017 WP_047332101.1 NZ_CP011773:c5167196-5166750 [Mycobacterium sp. EPa45]
MAKLSVSVDVPLPPEQAWQHASDLSRYKDWLTIHRVWRSKLPETLEKGTVVESIVEVKGMPNRVKWEIVHFKAPEAMTLN
GAGVGGVKVKLIGKVRANAKDPNTSVVTMDVHLGGAALFGPIGMVVAGALKGDIKESLDRFVAVFAPS

Download         Length: 447 bp

>T55017 NZ_CP011773:c5167196-5166750 [Mycobacterium sp. EPa45]
ATGGCGAAACTCTCAGTCTCCGTTGACGTTCCACTTCCACCAGAGCAGGCCTGGCAGCACGCGTCGGACCTCTCGCGCTA
CAAGGACTGGTTGACCATCCATCGGGTCTGGCGCTCGAAGCTGCCCGAAACGCTCGAAAAGGGCACCGTCGTGGAGTCCA
TCGTCGAGGTCAAGGGCATGCCCAACCGGGTGAAGTGGGAAATCGTCCACTTCAAGGCGCCGGAAGCCATGACGCTCAAC
GGCGCCGGCGTCGGCGGGGTGAAGGTCAAGCTGATCGGCAAGGTGCGGGCCAACGCCAAGGACCCCAACACCTCGGTGGT
GACCATGGACGTCCATCTGGGTGGCGCCGCGCTGTTCGGACCGATCGGCATGGTCGTGGCCGGTGCGCTGAAGGGCGACA
TCAAGGAGTCGCTGGACCGCTTCGTCGCGGTCTTCGCTCCGTCCTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7273.03 Da        Isoelectric Point: 4.9974

>AT55017 WP_047332102.1 NZ_CP011773:c5167405-5167199 [Mycobacterium sp. EPa45]
MGFLDKALGKTKEVLGENADKVGQAIDKAGDIIDQKTQGKYSGTVDKVQDAAKNYVDSNRTDKGDQPS

Download         Length: 207 bp

>AT55017 NZ_CP011773:c5167405-5167199 [Mycobacterium sp. EPa45]
ATGGGATTCCTCGACAAAGCCCTCGGCAAGACCAAAGAAGTCTTGGGTGAGAACGCCGACAAGGTAGGCCAGGCCATCGA
TAAGGCCGGCGACATCATCGATCAGAAGACGCAGGGCAAGTACTCCGGCACCGTCGACAAGGTGCAGGATGCGGCCAAGA
ACTATGTCGACTCCAACCGCACCGACAAAGGCGACCAACCCAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3IVI5

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3IT93

References