Detailed information of TA system TA055015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 183364..184176
• Replicon: plasmid p1
• Accession: NZ_CP011771
• Organism: Croceicoccus naphthovorans strain PQ-2

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A0G3XMU5
• Locus tag: AB433_RS18550
• Protein ID: WP_037486446.1
• Coordinates: 183364..183873 (-)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A0G3XL61
• Locus tag: AB433_RS18555
• Protein ID: WP_037486444.1
• Coordinates: 183877..184176 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB433_RS18520	179263..179951	+	689	Protein_191	pentapeptide repeat-containing protein	-
AB433_RS18525	179974..180162	-	189	WP_150113442.1	hypothetical protein	-
AB433_RS18530	180476..180820	+	345	WP_037486492.1	thermonuclease family protein	-
AB433_RS18535	181298..181633	+	336	WP_006949404.1	single-stranded DNA-binding protein	-
AB433_RS18540	182135..182692	+	558	WP_037486448.1	hypothetical protein	-
AB433_RS18545	182810..183298	+	489	WP_037486447.1	MucR family transcriptional regulator	-
AB433_RS18550	183364..183873	-	510	WP_037486446.1	GCN5 family acetyltransferase	Toxin
AB433_RS18555	183877..184176	-	300	WP_037486444.1	DUF1778 domain-containing protein	Antitoxin
AB433_RS18560	184252..184614	+	363	WP_037486442.1	hypothetical protein	-
AB433_RS18565	184952..185164	+	213	WP_007015874.1	helix-turn-helix transcriptional regulator	-
AB433_RS18570	185161..186402	+	1242	WP_007015873.1	type II toxin-antitoxin system HipA family toxin	-
AB433_RS18575	186784..187065	-	282	WP_007015872.1	hypothetical protein	-
AB433_RS18580	187628..188683	+	1056	WP_037486491.1	DUF2493 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..194680	194680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (14-86)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 17779.56 Da
• Isoelectric Point: 6.4739

>T55015 WP_037486446.1 NZ_CP011771:c183873-183364 [Croceicoccus naphthovorans]
MGLSPPELLNAAHEVDDFDCGKPSLNHWLKARALANQERGFTAVLVVHEAMRVVGYYGLAPTSVIPGILPRSIRTGQPPD
PVPCLLLGQLATDLAWAGQGIGSGLLRHALGRCLEAARLVGGRAVIVNAIDDEAAAFWLGKGFLPSRDDPLVLFQSIGAI
AASLAAAER

Nucleotide

• Length: 510 bp

>T55015 NZ_CP011771:c183873-183364 [Croceicoccus naphthovorans]
TTGGGCCTGTCGCCGCCGGAACTGTTGAACGCAGCTCATGAAGTCGATGACTTCGACTGCGGCAAGCCATCGCTCAATCA
CTGGCTCAAGGCGCGCGCCCTCGCAAACCAGGAGCGCGGGTTTACCGCGGTGTTGGTCGTGCATGAGGCGATGCGGGTGG
TCGGCTACTACGGGCTGGCTCCGACATCGGTGATCCCCGGCATTCTGCCGCGTTCCATCCGGACGGGGCAGCCGCCCGAT
CCAGTGCCTTGCCTGCTGCTCGGTCAACTCGCGACCGACCTGGCGTGGGCGGGACAGGGCATCGGCTCGGGATTGCTGCG
CCACGCACTGGGACGGTGTCTGGAAGCTGCCCGCCTTGTTGGCGGTCGTGCAGTGATCGTCAATGCCATCGACGACGAGG
CAGCGGCCTTCTGGCTAGGCAAGGGCTTCCTGCCTTCGCGCGACGATCCACTCGTGCTGTTCCAGTCGATCGGCGCCATT
GCTGCTTCCCTGGCAGCAGCAGAACGTTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11067.61 Da
• Isoelectric Point: 5.1859

>AT55015 WP_037486444.1 NZ_CP011771:c184176-183877 [Croceicoccus naphthovorans]
MAKSLERKDHPVSMRLPDADIALIDRAASARGRSRTDFVREAAVRAAEDVLMDQRLVRMSGEGFAEFIALLEQPAEAVPS
LVDVLRRPAPWDMPSDDRH

Nucleotide

• Length: 300 bp

>AT55015 NZ_CP011771:c184176-183877 [Croceicoccus naphthovorans]
ATGGCCAAGTCCCTTGAACGCAAGGATCACCCGGTATCGATGCGTCTGCCCGATGCCGACATTGCCCTGATCGATCGTGC
GGCAAGCGCGCGCGGGCGCTCGCGAACCGATTTCGTGCGAGAAGCAGCTGTGCGTGCTGCCGAGGATGTCCTGATGGACC
AGAGGCTCGTGCGGATGAGCGGCGAAGGGTTTGCCGAATTCATCGCGCTGCTGGAACAACCCGCCGAGGCGGTTCCATCG
CTCGTCGATGTGCTCAGGCGACCGGCGCCTTGGGACATGCCCTCGGACGATCGGCACTGA

Structures

Toxin

• AlphaFold DB: A0A0G3XMU5

Antitoxin

• AlphaFold DB: A0A0G3XL61