Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 7673..8485 Replicon plasmid p1
Accession NZ_CP011771
Organism Croceicoccus naphthovorans strain PQ-2

Toxin (Protein)


Gene name tacT Uniprot ID A0A0G3XMU5
Locus tag AB433_RS17635 Protein ID WP_037486446.1
Coordinates 7673..8182 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0G3XL61
Locus tag AB433_RS17640 Protein ID WP_037486444.1
Coordinates 8186..8485 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB433_RS20195 2708..3256 - 549 WP_082135083.1 DUF1173 family protein -
AB433_RS20720 3271..3420 + 150 WP_156170928.1 hypothetical protein -
AB433_RS17605 3573..4261 + 689 Protein_8 pentapeptide repeat-containing protein -
AB433_RS17610 4284..4472 - 189 WP_150113442.1 hypothetical protein -
AB433_RS17615 4786..5129 + 344 Protein_10 thermonuclease family protein -
AB433_RS17620 5607..5942 + 336 WP_006949404.1 single-stranded DNA-binding protein -
AB433_RS17625 6444..7001 + 558 WP_037486448.1 hypothetical protein -
AB433_RS17630 7119..7607 + 489 WP_037486447.1 MucR family transcriptional regulator -
AB433_RS17635 7673..8182 - 510 WP_037486446.1 GCN5 family acetyltransferase Toxin
AB433_RS17640 8186..8485 - 300 WP_037486444.1 DUF1778 domain-containing protein Antitoxin
AB433_RS17645 8561..8923 + 363 WP_037486442.1 hypothetical protein -
AB433_RS17650 9261..9473 + 213 WP_007015874.1 helix-turn-helix transcriptional regulator -
AB433_RS17655 9470..10711 + 1242 WP_007015873.1 type II toxin-antitoxin system HipA family toxin -
AB433_RS17660 11093..11374 - 282 WP_007015872.1 hypothetical protein -
AB433_RS17665 11938..12993 + 1056 WP_037486491.1 DUF2493 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..194680 194680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(14-86)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 17779.56 Da        Isoelectric Point: 6.4739

>T55013 WP_037486446.1 NZ_CP011771:c8182-7673 [Croceicoccus naphthovorans]
MGLSPPELLNAAHEVDDFDCGKPSLNHWLKARALANQERGFTAVLVVHEAMRVVGYYGLAPTSVIPGILPRSIRTGQPPD
PVPCLLLGQLATDLAWAGQGIGSGLLRHALGRCLEAARLVGGRAVIVNAIDDEAAAFWLGKGFLPSRDDPLVLFQSIGAI
AASLAAAER

Download         Length: 510 bp

>T55013 NZ_CP011771:c8182-7673 [Croceicoccus naphthovorans]
TTGGGCCTGTCGCCGCCGGAACTGTTGAACGCAGCTCATGAAGTCGATGACTTCGACTGCGGCAAGCCATCGCTCAATCA
CTGGCTCAAGGCGCGCGCCCTCGCAAACCAGGAGCGCGGGTTTACCGCGGTGTTGGTCGTGCATGAGGCGATGCGGGTGG
TCGGCTACTACGGGCTGGCTCCGACATCGGTGATCCCCGGCATTCTGCCGCGTTCCATCCGGACGGGGCAGCCGCCCGAT
CCAGTGCCTTGCCTGCTGCTCGGTCAACTCGCGACCGACCTGGCGTGGGCGGGACAGGGCATCGGCTCGGGATTGCTGCG
CCACGCACTGGGACGGTGTCTGGAAGCTGCCCGCCTTGTTGGCGGTCGTGCAGTGATCGTCAATGCCATCGACGACGAGG
CAGCGGCCTTCTGGCTAGGCAAGGGCTTCCTGCCTTCGCGCGACGATCCACTCGTGCTGTTCCAGTCGATCGGCGCCATT
GCTGCTTCCCTGGCAGCAGCAGAACGTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11067.61 Da        Isoelectric Point: 5.1859

>AT55013 WP_037486444.1 NZ_CP011771:c8485-8186 [Croceicoccus naphthovorans]
MAKSLERKDHPVSMRLPDADIALIDRAASARGRSRTDFVREAAVRAAEDVLMDQRLVRMSGEGFAEFIALLEQPAEAVPS
LVDVLRRPAPWDMPSDDRH

Download         Length: 300 bp

>AT55013 NZ_CP011771:c8485-8186 [Croceicoccus naphthovorans]
ATGGCCAAGTCCCTTGAACGCAAGGATCACCCGGTATCGATGCGTCTGCCCGATGCCGACATTGCCCTGATCGATCGTGC
GGCAAGCGCGCGCGGGCGCTCGCGAACCGATTTCGTGCGAGAAGCAGCTGTGCGTGCTGCCGAGGATGTCCTGATGGACC
AGAGGCTCGTGCGGATGAGCGGCGAAGGGTTTGCCGAATTCATCGCGCTGCTGGAACAACCCGCCGAGGCGGTTCCATCG
CTCGTCGATGTGCTCAGGCGACCGGCGCCTTGGGACATGCCCTCGGACGATCGGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3XMU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3XL61

References