Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3161172..3161737 Replicon chromosome
Accession NZ_CP011770
Organism Croceicoccus naphthovorans strain PQ-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3XKD5
Locus tag AB433_RS15565 Protein ID WP_047822288.1
Coordinates 3161172..3161543 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3XIT1
Locus tag AB433_RS15570 Protein ID WP_047822290.1
Coordinates 3161540..3161737 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB433_RS15540 3156767..3157039 - 273 WP_047822280.1 VirB3 family type IV secretion system protein -
AB433_RS15545 3157039..3157371 - 333 WP_047822282.1 TrbC/VirB2 family protein -
AB433_RS15550 3157368..3158390 - 1023 WP_053059213.1 P-type conjugative transfer ATPase TrbB -
AB433_RS15555 3158535..3158972 - 438 WP_047824279.1 CopG domain-containing protein -
AB433_RS15560 3158989..3160989 - 2001 WP_047822286.1 conjugal transfer protein TraG -
AB433_RS15565 3161172..3161543 - 372 WP_047822288.1 type II toxin-antitoxin system VapC family toxin Toxin
AB433_RS15570 3161540..3161737 - 198 WP_047822290.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AB433_RS15575 3161839..3163590 - 1752 WP_047822292.1 VirD2 family relaxase/mobilization nuclease -
AB433_RS15580 3164111..3165184 - 1074 WP_047822294.1 IS110 family transposase -
AB433_RS15585 3165375..3166103 - 729 WP_053059295.1 lytic transglycosylase domain-containing protein -
AB433_RS15590 3166108..3166443 - 336 WP_039577893.1 DUF736 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3095362..3199474 104112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13837.92 Da        Isoelectric Point: 6.9899

>T55012 WP_047822288.1 NZ_CP011770:c3161543-3161172 [Croceicoccus naphthovorans]
MILVDSTVWVDHLRQGDPLLVSRLEAGLVFSHPFIIGEIALGSLRQRDKVLSSLRDLPRTKQATDEEVQAFIEHQPLYSL
GIGYVDAHLLAATRLTTGMRLWTRDRRLNDIATRLGVAEAVQH

Download         Length: 372 bp

>T55012 NZ_CP011770:c3161543-3161172 [Croceicoccus naphthovorans]
ATGATTCTCGTCGATAGCACTGTCTGGGTTGATCACCTCAGGCAAGGCGATCCGCTGCTTGTGAGCCGCCTCGAAGCCGG
GCTTGTCTTCAGCCACCCGTTCATCATCGGCGAGATCGCGCTGGGCAGTTTGCGACAGCGCGACAAGGTGCTTTCGTCGC
TACGGGATTTGCCACGAACGAAGCAGGCCACCGACGAAGAGGTTCAGGCGTTCATTGAGCATCAGCCTCTCTACAGCCTC
GGCATCGGCTACGTTGACGCCCATCTACTCGCAGCCACACGGCTGACAACGGGAATGCGTCTATGGACACGCGATAGGCG
CTTGAATGACATAGCAACGCGCCTTGGAGTTGCTGAAGCCGTTCAGCACTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7310.40 Da        Isoelectric Point: 8.8337

>AT55012 WP_047822290.1 NZ_CP011770:c3161737-3161540 [Croceicoccus naphthovorans]
MRTTIVLDDEQLAKAQAFTGLKEKSQLVREAFKALIERESARRLVLLGGSEPDLEIPARRRSTAE

Download         Length: 198 bp

>AT55012 NZ_CP011770:c3161737-3161540 [Croceicoccus naphthovorans]
ATGCGAACAACTATCGTTCTTGATGACGAACAGCTTGCGAAGGCACAGGCATTCACTGGTCTCAAAGAGAAATCTCAGCT
CGTGCGCGAGGCGTTCAAGGCCCTCATCGAACGCGAAAGTGCTCGGCGTCTCGTCTTGCTTGGCGGAAGCGAACCCGACC
TTGAAATCCCAGCCCGCCGCCGGTCCACCGCTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3XKD5

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3XIT1

References