Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3055602..3057127 Replicon chromosome
Accession NZ_CP011770
Organism Croceicoccus naphthovorans strain PQ-2

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag AB433_RS15135 Protein ID WP_156170845.1
Coordinates 3055602..3056873 (-) Length 424 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag AB433_RS15140 Protein ID WP_047822160.1
Coordinates 3056870..3057127 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB433_RS15125 3050740..3053607 - 2868 WP_047822153.1 class I SAM-dependent DNA methyltransferase -
AB433_RS15130 3053617..3055464 - 1848 WP_156170844.1 DUF262 domain-containing protein -
AB433_RS15135 3055602..3056873 - 1272 WP_156170845.1 type II toxin-antitoxin system HipA family toxin Toxin
AB433_RS15140 3056870..3057127 - 258 WP_047822160.1 helix-turn-helix transcriptional regulator Antitoxin
AB433_RS15145 3057544..3058407 + 864 WP_047822162.1 phosphatidylserine decarboxylase -
AB433_RS15150 3058427..3059323 + 897 WP_047822164.1 histone deacetylase -
AB433_RS15155 3059386..3059793 + 408 WP_047822166.1 hypothetical protein -
AB433_RS20640 3059800..3059970 - 171 WP_156170846.1 hypothetical protein -
AB433_RS15160 3060071..3061717 - 1647 WP_156170847.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-63)


Sequences

Toxin        


Download         Length: 424 a.a.        Molecular weight: 45334.96 Da        Isoelectric Point: 5.1142

>T55011 WP_156170845.1 NZ_CP011770:c3056873-3055602 [Croceicoccus naphthovorans]
VMLPVLDTLVVWWGERQAGELSIDKGGAMHFVYLPEWLADDKAPALSHAMPKQEGPFGDHACKAVFGGLLPEEGQRTAIA
RALGVSPDNPFRLLEALGGDVAGTLAFLPEGEELFQAYSTTAPEPLLEGELAELFNRLPSVPMLAGEGGARLSLAGAQSK
LPVVLTAEGGIAIPRPGEPSTHLIKPEPDRFPYLAANEAFCLALARAVGIDAAHAEWRTAAGKPFLLVERYDRISVEGKT
HRLHQEDFAQALGVPSNRKYAAEGGPTFRDGFALLRSAATRPAREVLKLADAAIFNLIIGNADAHAKNYSLLRLENGEVA
LAPLYDVVATHMWKQLSPKLAMRFGRAATVEEFDIGNVARFAEEAGLGAPFIRRRLADLTEAVRAEIEKGVQVPGNPAEE
MVAPVAEALSARASIVALKLLET

Download         Length: 1272 bp

>T55011 NZ_CP011770:c3056873-3055602 [Croceicoccus naphthovorans]
GTGATGCTGCCGGTCTTGGACACGCTGGTTGTCTGGTGGGGCGAGCGTCAGGCGGGCGAACTGTCCATCGACAAGGGTGG
TGCGATGCACTTCGTCTATTTGCCGGAATGGCTCGCTGACGACAAGGCACCGGCACTTTCCCACGCAATGCCTAAGCAGG
AAGGGCCATTTGGGGACCATGCCTGCAAGGCGGTCTTTGGCGGTCTGCTTCCCGAAGAAGGTCAGCGCACCGCTATCGCC
CGGGCACTTGGGGTTTCGCCTGACAATCCATTTCGTCTGCTCGAGGCCTTGGGCGGAGATGTTGCGGGTACTCTGGCCTT
CCTGCCCGAGGGGGAAGAGCTGTTCCAAGCCTACTCCACGACCGCTCCAGAACCACTCCTAGAGGGCGAGCTAGCGGAAC
TATTCAACCGTTTGCCTTCCGTGCCCATGCTGGCAGGCGAGGGCGGCGCAAGGCTGAGCCTTGCAGGGGCTCAGAGTAAA
CTGCCCGTGGTGCTCACCGCAGAAGGAGGCATCGCGATCCCTCGTCCGGGCGAACCCTCTACCCATTTAATAAAGCCCGA
ACCGGACCGCTTTCCCTACCTGGCTGCGAATGAGGCCTTCTGCCTCGCTTTGGCACGCGCCGTGGGTATCGATGCAGCCC
ATGCAGAGTGGCGCACTGCTGCGGGGAAACCGTTCCTGCTGGTTGAACGCTATGATCGCATCTCGGTTGAAGGAAAAACA
CACCGACTGCACCAGGAAGACTTCGCCCAAGCACTTGGCGTACCCTCGAACCGAAAATACGCGGCAGAGGGTGGACCGAC
CTTTCGGGACGGCTTTGCGCTGTTGCGTAGCGCTGCCACTCGACCCGCACGCGAAGTGCTGAAACTTGCCGACGCGGCAA
TCTTCAACCTCATCATCGGCAACGCCGACGCTCACGCGAAGAATTACAGCCTGCTAAGACTTGAGAACGGCGAAGTGGCG
CTTGCCCCGCTTTACGATGTCGTCGCCACACACATGTGGAAGCAACTCTCGCCAAAGCTCGCGATGCGATTTGGCCGCGC
CGCGACCGTGGAGGAATTCGACATCGGGAACGTCGCGCGCTTCGCGGAAGAGGCCGGGCTGGGTGCGCCTTTCATCCGTC
GCCGGTTGGCTGACCTTACTGAAGCGGTGAGGGCGGAGATTGAGAAGGGTGTTCAGGTGCCCGGCAATCCGGCTGAGGAA
ATGGTCGCGCCGGTCGCAGAGGCATTATCGGCTCGTGCCAGCATCGTTGCCTTGAAGCTCTTAGAGACATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9300.86 Da        Isoelectric Point: 4.8779

>AT55011 WP_047822160.1 NZ_CP011770:c3057127-3056870 [Croceicoccus naphthovorans]
MLDVATIGKIIRDERKELGLRQDELAAASGVGLRFLVELERGKPTVQMGKVLDVLAALGCELQIKRPDGIVTAGRMDEPK
KDEVE

Download         Length: 258 bp

>AT55011 NZ_CP011770:c3057127-3056870 [Croceicoccus naphthovorans]
ATGCTCGATGTTGCCACTATCGGCAAGATCATTCGCGATGAACGCAAGGAGCTTGGACTACGCCAGGACGAGCTGGCCGC
CGCAAGCGGGGTGGGCCTGCGCTTTTTGGTCGAGCTGGAGCGAGGAAAGCCCACCGTCCAAATGGGCAAGGTGCTTGATG
TGCTCGCGGCCCTTGGATGCGAACTACAGATCAAGCGGCCCGACGGAATCGTGACCGCCGGTCGAATGGATGAGCCTAAG
AAGGACGAGGTGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References