Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2135192..2135865 Replicon chromosome
Accession NZ_CP011770
Organism Croceicoccus naphthovorans strain PQ-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3XIX2
Locus tag AB433_RS10775 Protein ID WP_047820988.1
Coordinates 2135443..2135865 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3XGK1
Locus tag AB433_RS10770 Protein ID WP_012110103.1
Coordinates 2135192..2135446 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB433_RS10755 2132798..2133832 + 1035 WP_047820985.1 toprim domain-containing protein -
AB433_RS10765 2134180..2135106 + 927 WP_047820987.1 DUF2493 domain-containing protein -
AB433_RS10770 2135192..2135446 + 255 WP_012110103.1 plasmid stabilization protein Antitoxin
AB433_RS10775 2135443..2135865 + 423 WP_047820988.1 type II toxin-antitoxin system VapC family toxin Toxin
AB433_RS20850 2136147..2136314 + 168 WP_012110101.1 hypothetical protein -
AB433_RS10780 2136449..2136889 + 441 WP_047820989.1 hypothetical protein -
AB433_RS10790 2137463..2137789 + 327 WP_041535876.1 DUF736 domain-containing protein -
AB433_RS10795 2138096..2138362 + 267 WP_045811379.1 helix-turn-helix transcriptional regulator -
AB433_RS10800 2138417..2138719 + 303 WP_082134894.1 DUF2285 domain-containing protein -
AB433_RS10805 2139081..2139611 + 531 WP_053059123.1 DUF2285 domain-containing protein -
AB433_RS10810 2139748..2140029 + 282 WP_012110094.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1995834..2197712 201878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14914.07 Da        Isoelectric Point: 4.5187

>T55010 WP_047820988.1 NZ_CP011770:2135443-2135865 [Croceicoccus naphthovorans]
MILLDTNVVSEAMKPAPDEAVRAWLDEQAAETLFLSSGTIAELMFGIGALPAGKRKERLTEALDGVMELFADRVLPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDSSAFEAANVTVIDPWKAER

Download         Length: 423 bp

>T55010 NZ_CP011770:2135443-2135865 [Croceicoccus naphthovorans]
ATGATCCTCCTCGACACCAATGTCGTATCGGAGGCGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGCGGCGGAAACACTCTTTCTCTCCAGCGGCACCATCGCCGAACTGATGTTCGGCATCGGCGCGCTCCCCGCCGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCGTCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGAGCGGCCGGGAAAGGCTTCCCTACTCCCGACGGCTACATCGC
GGCGATCGCAGCCGCCAAGGGGTTTGCCGTCGCCACGCGCGACAGCAGCGCATTCGAGGCCGCGAATGTCACGGTGATCG
ATCCCTGGAAGGCCGAGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9351.67 Da        Isoelectric Point: 10.4317

>AT55010 WP_012110103.1 NZ_CP011770:2135192-2135446 [Croceicoccus naphthovorans]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDQARDKAPAKP
MSFE

Download         Length: 255 bp

>AT55010 NZ_CP011770:2135192-2135446 [Croceicoccus naphthovorans]
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCATCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATTCTCGAAATGGCTGTCCGCCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCAGGCTCGTGACAAGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3XIX2

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3XGK1

References