Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2120963..2121441 Replicon chromosome
Accession NZ_CP011685
Organism Staphylococcus aureus strain ZJ5499

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag AB179_RS10770 Protein ID WP_063653188.1
Coordinates 2120963..2121289 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag AB179_RS10775 Protein ID WP_025175789.1
Coordinates 2121292..2121441 (-) Length 50 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB179_RS10745 2116187..2116528 - 342 WP_001190615.1 hypothetical protein -
AB179_RS10750 2116978..2117619 - 642 WP_001047698.1 hypothetical protein -
AB179_RS10755 2117616..2117996 - 381 WP_000356942.1 hypothetical protein -
AB179_RS10760 2118306..2120015 - 1710 WP_000447473.1 DUF927 domain-containing protein -
AB179_RS10765 2120029..2120898 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
AB179_RS10770 2120963..2121289 - 327 WP_063653188.1 DUF1474 family protein Toxin
AB179_RS10775 2121292..2121441 - 150 WP_025175789.1 hypothetical protein Antitoxin
AB179_RS10780 2121494..2121640 - 147 WP_000784885.1 hypothetical protein -
AB179_RS10785 2121637..2121954 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
AB179_RS10790 2121959..2122177 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
AB179_RS10795 2122350..2123024 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
AB179_RS10800 2123038..2124210 + 1173 WP_000179343.1 site-specific integrase -
AB179_RS10805 2124279..2125895 - 1617 WP_000240642.1 chaperonin GroEL -
AB179_RS10810 2125971..2126255 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / sell / sec / tsst-1 / groEL 2060084..2126255 66171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12896.19 Da        Isoelectric Point: 4.3528

>T54835 WP_063653188.1 NZ_CP011685:c2121289-2120963 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDGLIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T54835 NZ_CP011685:c2121289-2120963 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGGATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 50 a.a.        Molecular weight: 5822.52 Da        Isoelectric Point: 4.4876

>AT54835 WP_025175789.1 NZ_CP011685:c2121441-2121292 [Staphylococcus aureus]
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 150 bp

>AT54835 NZ_CP011685:c2121441-2121292 [Staphylococcus aureus]
GTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCA
CTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References