Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 872640..873117 Replicon chromosome
Accession NZ_CP011685
Organism Staphylococcus aureus strain ZJ5499

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AB179_RS04235 Protein ID WP_000052076.1
Coordinates 872640..872828 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AB179_RS04240 Protein ID WP_001059690.1
Coordinates 872857..873117 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB179_RS04205 868634..869155 + 522 WP_000824482.1 hypothetical protein -
AB179_RS04210 869496..870182 + 687 WP_000141557.1 thermonuclease family protein -
AB179_RS04215 870539..870739 + 201 WP_001059082.1 cold-shock protein -
AB179_RS04220 871231..871449 - 219 WP_000005886.1 hypothetical protein -
AB179_RS04225 871511..871795 - 285 WP_001004399.1 hypothetical protein -
AB179_RS04230 871883..872452 - 570 WP_001106654.1 hypothetical protein -
AB179_RS04235 872640..872828 - 189 WP_000052076.1 hypothetical protein Toxin
AB179_RS04240 872857..873117 - 261 WP_001059690.1 hypothetical protein Antitoxin
AB179_RS04245 873458..873661 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AB179_RS04250 873658..873894 - 237 WP_000349581.1 hypothetical protein -
AB179_RS04255 874119..874700 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
AB179_RS04260 874773..875390 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
AB179_RS04265 875545..876039 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AB179_RS04270 876438..876860 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AB179_RS04275 877008..877724 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-147)

Antitoxin

Vibrio phage ICP1, Orf50

(25-100)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T54824 WP_000052076.1 NZ_CP011685:c872828-872640 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T54824 NZ_CP011685:c872828-872640 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT54824 WP_001059690.1 NZ_CP011685:c873117-872857 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT54824 NZ_CP011685:c873117-872857 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References