Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 846090..846619 Replicon chromosome
Accession NZ_CP011685
Organism Staphylococcus aureus strain ZJ5499

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag AB179_RS04075 Protein ID WP_001103933.1
Coordinates 846302..846619 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag AB179_RS04070 Protein ID WP_001058487.1
Coordinates 846090..846299 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB179_RS04035 842541..843005 + 465 WP_001085183.1 SsrA-binding protein SmpB -
AB179_RS04045 843568..844674 - 1107 WP_000121223.1 site-specific integrase -
AB179_RS04050 844680..845327 - 648 WP_072474260.1 helix-turn-helix domain-containing protein -
AB179_RS04055 845485..845691 + 207 WP_001060953.1 hypothetical protein -
AB179_RS04060 845727..845954 + 228 WP_000164237.1 helix-turn-helix domain-containing protein -
AB179_RS04065 845951..846097 + 147 WP_000784893.1 hypothetical protein -
AB179_RS04070 846090..846299 + 210 WP_001058487.1 hypothetical protein Antitoxin
AB179_RS04075 846302..846619 + 318 WP_001103933.1 DUF1474 family protein Toxin
AB179_RS04080 846686..847555 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
AB179_RS04085 847572..849041 + 1470 WP_001668899.1 virulence-associated E family protein -
AB179_RS04090 849327..849689 + 363 WP_001039169.1 hypothetical protein -
AB179_RS04095 849691..849975 + 285 WP_000998179.1 hypothetical protein -
AB179_RS04100 849972..850613 + 642 WP_001019810.1 hypothetical protein -
AB179_RS04105 851063..851404 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 840147..855382 15235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T54823 WP_001103933.1 NZ_CP011685:846302-846619 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T54823 NZ_CP011685:846302-846619 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT54823 WP_001058487.1 NZ_CP011685:846090-846299 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT54823 NZ_CP011685:846090-846299 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References