Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3290276..3290805 Replicon chromosome
Accession NZ_CP011664
Organism Streptomyces sp. Mg1

Toxin (Protein)


Gene name relE Uniprot ID B4VEP6
Locus tag M444_RS14050 Protein ID WP_008743447.1
Coordinates 3290548..3290805 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4VEP7
Locus tag M444_RS14045 Protein ID WP_008743448.1
Coordinates 3290276..3290551 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M444_RS14030 3286434..3287804 - 1371 WP_008743451.1 NarK/NasA family nitrate transporter -
M444_RS14035 3287902..3288864 - 963 WP_037795028.1 LysR family transcriptional regulator -
M444_RS14040 3288952..3290247 + 1296 WP_086025432.1 MFS transporter -
M444_RS14045 3290276..3290551 + 276 WP_008743448.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M444_RS14050 3290548..3290805 + 258 WP_008743447.1 Txe/YoeB family addiction module toxin Toxin
M444_RS14055 3291342..3291827 - 486 WP_008743446.1 SsrA-binding protein SmpB -
M444_RS14060 3291846..3293048 - 1203 WP_037797668.1 PDZ domain-containing protein -
M444_RS14065 3293116..3294081 - 966 WP_008743442.1 permease-like cell division protein FtsX -
M444_RS14070 3294098..3294787 - 690 WP_008743441.1 cell division ATP-binding protein FtsE -
M444_RS14075 3295017..3295208 + 192 WP_008743440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10175.62 Da        Isoelectric Point: 10.0901

>T54822 WP_008743447.1 NZ_CP011664:3290548-3290805 [Streptomyces sp. Mg1]
VRSVHFDPAAWEDFLFRLSSDRKMARRITRLIGEIQRDPFTGIGKPEPLKGELTGYWSRRIDDEHRLVYRADDKEVKVLK
ARYHY

Download         Length: 258 bp

>T54822 NZ_CP011664:3290548-3290805 [Streptomyces sp. Mg1]
GTGAGGAGCGTTCACTTCGACCCCGCCGCCTGGGAGGACTTCCTGTTCCGGCTCTCCTCCGACCGCAAGATGGCCCGTCG
GATCACCCGCCTGATCGGCGAGATCCAGCGCGACCCGTTCACCGGGATCGGCAAGCCCGAGCCCCTGAAGGGCGAACTGA
CCGGTTACTGGTCCCGCCGGATCGACGACGAACACCGCCTCGTGTACCGGGCGGACGACAAGGAAGTGAAGGTGCTCAAG
GCCCGGTATCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10079.26 Da        Isoelectric Point: 4.5098

>AT54822 WP_008743448.1 NZ_CP011664:3290276-3290551 [Streptomyces sp. Mg1]
MSISASEARATLFPLIERVNTDHDPVRITSKNGDAVLMSADDYDSWQETVYLLRSPANAQRLMEAVARDREGAPAVTKSM
EELRRLAGGEE

Download         Length: 276 bp

>AT54822 NZ_CP011664:3290276-3290551 [Streptomyces sp. Mg1]
ATGTCGATAAGCGCCAGTGAAGCCAGGGCGACCCTGTTCCCCTTGATCGAACGCGTCAACACCGACCACGACCCGGTGCG
CATCACCTCCAAGAACGGCGACGCCGTCCTGATGTCCGCCGACGACTACGACTCCTGGCAGGAGACGGTCTACCTGCTGC
GCTCCCCCGCCAACGCCCAGAGGCTGATGGAGGCCGTCGCCCGCGATCGCGAGGGCGCGCCCGCGGTCACCAAGTCCATG
GAAGAGCTGAGGCGGTTGGCCGGAGGGGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N6EKL1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N6GF48

References